Guise CP - Search Results

1

E. coli nitroreductase NfsA is a reporter gene for non-invasive PET imaging in cancer gene therapy applications.

Mowday AM, Copp JN, Syddall SP, Dubois LJ, Wang J, Lieuwes NG, Biemans R, Ashoorzadeh A, Abbattista MR, Williams EM, Guise CP, Lambin P, Ackerley DF, Smaill JB, Theys J, Patterson AV. Mowday AM, et al. Among authors: guise cp. Theranostics. 2020 Aug 21;10(23):10548-10562. doi: 10.7150/thno.46826. eCollection 2020. Theranostics. 2020. PMID: 32929365 Free PMC article.

2

Identification of human reductases that activate the dinitrobenzamide mustard prodrug PR-104A: a role for NADPH:cytochrome P450 oxidoreductase under hypoxia.

Guise CP, Wang AT, Theil A, Bridewell DJ, Wilson WR, Patterson AV. Guise CP, et al. Biochem Pharmacol. 2007 Sep 15;74(6):810-20. doi: 10.1016/j.bcp.2007.06.014. Epub 2007 Jun 17. Biochem Pharmacol. 2007. PMID: 17645874

3

DNA cross-links in human tumor cells exposed to the prodrug PR-104A: relationships to hypoxia, bioreductive metabolism, and cytotoxicity.

Singleton RS, Guise CP, Ferry DM, Pullen SM, Dorie MJ, Brown JM, Patterson AV, Wilson WR. Singleton RS, et al. Among authors: guise cp. Cancer Res. 2009 May 1;69(9):3884-91. doi: 10.1158/0008-5472.CAN-08-4023. Epub 2009 Apr 14. Cancer Res. 2009. PMID: 19366798

4

The bioreductive prodrug PR-104A is activated under aerobic conditions by human aldo-keto reductase 1C3.

Guise CP, Abbattista MR, Singleton RS, Holford SD, Connolly J, Dachs GU, Fox SB, Pollock R, Harvey J, Guilford P, Doñate F, Wilson WR, Patterson AV. Guise CP, et al. Cancer Res. 2010 Feb 15;70(4):1573-84. doi: 10.1158/0008-5472.CAN-09-3237. Epub 2010 Feb 9. Cancer Res. 2010. PMID: 20145130

5

Reductive metabolism of the dinitrobenzamide mustard anticancer prodrug PR-104 in mice.

Gu Y, Guise CP, Patel K, Abbattista MR, Li J, Sun X, Atwell GJ, Boyd M, Patterson AV, Wilson WR. Gu Y, et al. Among authors: guise cp. Cancer Chemother Pharmacol. 2011 Mar;67(3):543-55. doi: 10.1007/s00280-010-1354-5. Epub 2010 May 15. Cancer Chemother Pharmacol. 2011. PMID: 20473609

6

Diflavin oxidoreductases activate the bioreductive prodrug PR-104A under hypoxia.

Guise CP, Abbattista MR, Tipparaju SR, Lambie NK, Su J, Li D, Wilson WR, Dachs GU, Patterson AV. Guise CP, et al. Mol Pharmacol. 2012 Jan;81(1):31-40. doi: 10.1124/mol.111.073759. Epub 2011 Oct 7. Mol Pharmacol. 2012. PMID: 21984255

7

Molecular and cellular pharmacology of the hypoxia-activated prodrug TH-302.

Meng F, Evans JW, Bhupathi D, Banica M, Lan L, Lorente G, Duan JX, Cai X, Mowday AM, Guise CP, Maroz A, Anderson RF, Patterson AV, Stachelek GC, Glazer PM, Matteucci MD, Hart CP. Meng F, et al. Among authors: guise cp. Mol Cancer Ther. 2012 Mar;11(3):740-51. doi: 10.1158/1535-7163.MCT-11-0634. Epub 2011 Dec 6. Mol Cancer Ther. 2012. PMID: 22147748

8

Targeted mutagenesis of the Vibrio fischeri flavin reductase FRase I to improve activation of the anticancer prodrug CB1954.

Swe PM, Copp JN, Green LK, Guise CP, Mowday AM, Smaill JB, Patterson AV, Ackerley DF. Swe PM, et al. Among authors: guise cp. Biochem Pharmacol. 2012 Sep 15;84(6):775-83. doi: 10.1016/j.bcp.2012.07.002. Epub 2012 Jul 14. Biochem Pharmacol. 2012. PMID: 22796568

9

Creation and screening of a multi-family bacterial oxidoreductase library to discover novel nitroreductases that efficiently activate the bioreductive prodrugs CB1954 and PR-104A.

Prosser GA, Copp JN, Mowday AM, Guise CP, Syddall SP, Williams EM, Horvat CN, Swe PM, Ashoorzadeh A, Denny WA, Smaill JB, Patterson AV, Ackerley DF. Prosser GA, et al. Among authors: guise cp. Biochem Pharmacol. 2013 Apr 15;85(8):1091-103. doi: 10.1016/j.bcp.2013.01.029. Epub 2013 Feb 8. Biochem Pharmacol. 2013. PMID: 23399641

10

Pseudomonas aeruginosa NfsB and nitro-CBI-DEI--a promising enzyme/prodrug combination for gene directed enzyme prodrug therapy.

Green LK, Syddall SP, Carlin KM, Bell GD, Guise CP, Mowday AM, Hay MP, Smaill JB, Patterson AV, Ackerley DF. Green LK, et al. Among authors: guise cp. Mol Cancer. 2013 Jun 10;12:58. doi: 10.1186/1476-4598-12-58. Mol Cancer. 2013. PMID: 23758947 Free PMC article.

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