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FGF18-FGFR2 signaling triggers the activation of c-Jun-YAP1 axis to promote carcinogenesis in a subgroup of gastric cancer patients and indicates translational potential.
Zhang J, Wong CC, Leung KT, Wu F, Zhou Y, Tong JHM, Chan RCK, Li H, Wang Y, Yan H, Liu L, Wu WKK, Chan MWY, Cheng ASL, Yu J, Wong N, Lo KW, To KF, Kang W. Zhang J, et al. Among authors: liu l. Oncogene. 2020 Oct;39(43):6647-6663. doi: 10.1038/s41388-020-01458-x. Epub 2020 Sep 15. Oncogene. 2020. PMID: 32934314 Free PMC article.
FGF18, a prominent player in FGF signaling, promotes gastric tumorigenesis through autocrine manner and is negatively regulated by miR-590-5p.
Zhang J, Zhou Y, Huang T, Wu F, Pan Y, Dong Y, Wang Y, Chan AKY, Liu L, Kwan JSH, Cheung AHK, Wong CC, Lo AKF, Cheng ASL, Yu J, Lo KW, Kang W, To KF. Zhang J, et al. Among authors: liu l. Oncogene. 2019 Jan;38(1):33-46. doi: 10.1038/s41388-018-0430-x. Epub 2018 Aug 6. Oncogene. 2019. PMID: 30082912 Free PMC article.
AMOTL1 enhances YAP1 stability and promotes YAP1-driven gastric oncogenesis.
Zhou Y, Zhang J, Li H, Huang T, Wong CC, Wu F, Wu M, Weng N, Liu L, Cheng ASL, Yu J, Wong N, Lo KW, Tang PMK, Kang W, To KF. Zhou Y, et al. Among authors: liu l. Oncogene. 2020 May;39(22):4375-4389. doi: 10.1038/s41388-020-1293-5. Epub 2020 Apr 20. Oncogene. 2020. PMID: 32313226 Free PMC article.
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