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Metabolic programs define dysfunctional immune responses in severe COVID-19 patients.
Thompson EA, Cascino K, Ordonez AA, Zhou W, Vaghasia A, Hamacher-Brady A, Brady NR, Sun IH, Wang R, Rosenberg AZ, Delannoy M, Rothman R, Fenstermacher K, Sauer L, Shaw-Saliba K, Bloch EM, Redd AD, Tobian AA, Horton M, Smith K, Pekosz A, D'Alessio FR, Yegnasubramanian S, Ji H, Cox AL, Powell JD. Thompson EA, et al. medRxiv [Preprint]. 2020 Oct 5:2020.09.10.20186064. doi: 10.1101/2020.09.10.20186064. medRxiv. 2020. Update in: Cell Rep. 2021 Mar 16;34(11):108863. doi: 10.1016/j.celrep.2021.108863 PMID: 32935120 Free PMC article. Updated. Preprint.
MK2 nonenzymatically promotes nuclear translocation of caspase-3 and resultant apoptosis.
Del Rosario O, Suresh K, Kallem M, Singh G, Shah A, Zheng L, Yun X, Philip NM, Putcha N, McClure MB, Jiang H, D'Alessio F, Srivastava M, Bera A, Shimoda LA, Merchant M, Rane MJ, Machamer CE, Mock J, Hagan R, Koch AL, Punjabi NM, Kolb TM, Damarla M. Del Rosario O, et al. Am J Physiol Lung Cell Mol Physiol. 2023 May 1;324(5):L700-L711. doi: 10.1152/ajplung.00340.2022. Epub 2023 Mar 28. Am J Physiol Lung Cell Mol Physiol. 2023. PMID: 36976920 Free PMC article.
Guide to assembling a successful K99/R00 application.
Michaely P, Bielinski SJ, Campbell K, D'Alessio F, Dean D, Earley YF, Paine R 3rd, Salama G, Peter I. Michaely P, et al. J Clin Transl Sci. 2023 Sep 29;7(1):e215. doi: 10.1017/cts.2023.639. eCollection 2023. J Clin Transl Sci. 2023. PMID: 37900348 Free PMC article.
Tumor MK2 transcript levels are associated with improved response to chemotherapy and patient survival in non-small cell lung cancer.
Suresh K, Del Rosario O, Kallem M, Singh G, Shah A, Zheng L, Yun X, Philip NM, Putcha N, McClure MB, Jiang H, D'Alessio F, Srivastava M, Bera A, Shimoda LA, Merchant M, Rane MJ, Machamer CE, Mock J, Hagan R, Koch AL, Punjabi NM, Kolb TM, Damarla M. Suresh K, et al. Physiol Genomics. 2023 Apr 1;55(4):168-178. doi: 10.1152/physiolgenomics.00155.2022. Epub 2023 Mar 6. Physiol Genomics. 2023. PMID: 36878491 Free PMC article.
Randomized, double-blinded, placebo-controlled trial of allogeneic cord blood T-regulatory cells for treatment of COVID-19 ARDS.
Gladstone DE, D'Alessio F, Howard C, Lyu MA, Mock JR, Gibbs KW, Abrams D, Huang M, Zeng K, Herlihy JP, Castillo ST, Bassett R, Sadeghi T, Parmar S, Flowers CR, Mukherjee S, Schoenfeld D, Thall PF, Slutsky AS. Gladstone DE, et al. Blood Adv. 2023 Jul 11;7(13):3075-3079. doi: 10.1182/bloodadvances.2022009619. Blood Adv. 2023. PMID: 36961352 Free PMC article. Clinical Trial. No abstract available.
Metabolic programs define dysfunctional immune responses in severe COVID-19 patients.
Thompson EA, Cascino K, Ordonez AA, Zhou W, Vaghasia A, Hamacher-Brady A, Brady NR, Sun IH, Wang R, Rosenberg AZ, Delannoy M, Rothman R, Fenstermacher K, Sauer L, Shaw-Saliba K, Bloch EM, Redd AD, Tobian AAR, Horton M, Smith K, Pekosz A, D'Alessio FR, Yegnasubramanian S, Ji H, Cox AL, Powell JD. Thompson EA, et al. Cell Rep. 2021 Mar 16;34(11):108863. doi: 10.1016/j.celrep.2021.108863. Epub 2021 Feb 26. Cell Rep. 2021. PMID: 33691089 Free PMC article.
Sulforaphane exhibits in vitro and in vivo antiviral activity against pandemic SARS-CoV-2 and seasonal HCoV-OC43 coronaviruses.
Ordonez AA, Bullen CK, Villabona-Rueda AF, Thompson EA, Turner ML, Davis SL, Komm O, Powell JD, D'Alessio FR, Yolken RH, Jain SK, Jones-Brando L. Ordonez AA, et al. bioRxiv [Preprint]. 2021 Mar 25:2021.03.25.437060. doi: 10.1101/2021.03.25.437060. bioRxiv. 2021. Update in: Commun Biol. 2022 Mar 18;5(1):242. doi: 10.1038/s42003-022-03189-z PMID: 33791708 Free PMC article. Updated. Preprint.
Functional characterization of CD4+ T cell receptors crossreactive for SARS-CoV-2 and endemic coronaviruses.
Dykema AG, Zhang B, Woldemeskel BA, Garliss CC, Cheung LS, Choudhury D, Zhang J, Aparicio L, Bom S, Rashid R, Caushi JX, Hsiue EH, Cascino K, Thompson EA, Kwaa AK, Singh D, Thapa S, Ordonez AA, Pekosz A, D'Alessio FR, Powell JD, Yegnasubramanian S, Zhou S, Pardoll DM, Ji H, Cox AL, Blankson JN, Smith KN. Dykema AG, et al. J Clin Invest. 2021 May 17;131(10):e146922. doi: 10.1172/JCI146922. J Clin Invest. 2021. PMID: 33830946 Free PMC article.
80 results