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Nitro-fatty acids suppress ischemic ventricular arrhythmias by preserving calcium homeostasis.
Mollenhauer M, Mehrkens D, Klinke A, Lange M, Remane L, Friedrichs K, Braumann S, Geißen S, Simsekyilmaz S, Nettersheim FS, Lee S, Peinkofer G, Geisler AC, Geis B, Schwoerer AP, Carrier L, Freeman BA, Dewenter M, Luo X, El-Armouche A, Wagner M, Adam M, Baldus S, Rudolph V. Mollenhauer M, et al. Sci Rep. 2020 Sep 18;10(1):15319. doi: 10.1038/s41598-020-71870-6. Sci Rep. 2020. PMID: 32948795 Free PMC article.
The new HNO donor, 1-nitrosocyclohexyl acetate, increases contractile force in normal and β-adrenergically desensitized ventricular myocytes.
El-Armouche A, Wahab A, Wittköpper K, Schulze T, Böttcher F, Pohlmann L, King SB, DuMond JF, Gerloff C, Böger RH, Eschenhagen T, Carrier L, Donzelli S. El-Armouche A, et al. Biochem Biophys Res Commun. 2010 Nov 12;402(2):340-4. doi: 10.1016/j.bbrc.2010.10.030. Epub 2010 Oct 12. Biochem Biophys Res Commun. 2010. PMID: 20946877
[Losmapimod: a novel drug against cardiovascular diseases?].
Dewenter M, Vettel C, El-Armouche A. Dewenter M, et al. Dtsch Med Wochenschr. 2013 Jan;138(1-2):39-42. doi: 10.1055/s-0032-1327368. Epub 2012 Dec 18. Dtsch Med Wochenschr. 2013. PMID: 23250695 Review. German.
145 results