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Acute SARS-CoV-2 Infection is Highly Cytopathic, Elicits a Robust Innate Immune Response and is Efficiently Prevented by EIDD-2801.
Wahl A, Gralinski L, Johnson C, Yao W, Kovarova M, Dinnon K, Liu H, Madden V, Krzystek H, De C, White K, Schäfer A, Zaman T, Leist S, Grant P, Gully K, Askin F, Browne E, Jones C, Pickles R, Baric R, Garcia JV. Wahl A, et al. Among authors: schafer a. Res Sq [Preprint]. 2020 Sep 24:rs.3.rs-80404. doi: 10.21203/rs.3.rs-80404/v1. Res Sq. 2020. Update in: Nature. 2021 Mar;591(7850):451-457. doi: 10.1038/s41586-021-03312-w PMID: 32995766 Free PMC article. Updated. Preprint.
Release of severe acute respiratory syndrome coronavirus nuclear import block enhances host transcription in human lung cells.
Sims AC, Tilton SC, Menachery VD, Gralinski LE, Schäfer A, Matzke MM, Webb-Robertson BJ, Chang J, Luna ML, Long CE, Shukla AK, Bankhead AR 3rd, Burkett SE, Zornetzer G, Tseng CT, Metz TO, Pickles R, McWeeney S, Smith RD, Katze MG, Waters KM, Baric RS. Sims AC, et al. Among authors: schafer a. J Virol. 2013 Apr;87(7):3885-902. doi: 10.1128/JVI.02520-12. Epub 2013 Jan 30. J Virol. 2013. PMID: 23365422 Free PMC article.
Systems approaches to Coronavirus pathogenesis.
Schäfer A, Baric RS, Ferris MT. Schäfer A, et al. Curr Opin Virol. 2014 Jun;6:61-9. doi: 10.1016/j.coviro.2014.04.007. Epub 2014 May 17. Curr Opin Virol. 2014. PMID: 24842079 Free PMC article. Review.
The effect of inhibition of PP1 and TNFα signaling on pathogenesis of SARS coronavirus.
McDermott JE, Mitchell HD, Gralinski LE, Eisfeld AJ, Josset L, Bankhead A 3rd, Neumann G, Tilton SC, Schäfer A, Li C, Fan S, McWeeney S, Baric RS, Katze MG, Waters KM. McDermott JE, et al. Among authors: schafer a. BMC Syst Biol. 2016 Sep 23;10(1):93. doi: 10.1186/s12918-016-0336-6. BMC Syst Biol. 2016. PMID: 27663205 Free PMC article.
Immune Predictors of Mortality After Ribonucleic Acid Virus Infection.
Graham JB, Swarts JL, Menachery VD, Gralinski LE, Schäfer A, Plante KS, Morrison CR, Voss KM, Green R, Choonoo G, Jeng S, Miller DR, Mooney MA, McWeeney SK, Ferris MT, Pardo-Manuel de Villena F, Gale M, Heise MT, Baric RS, Lund JM. Graham JB, et al. Among authors: schafer a. J Infect Dis. 2020 Mar 2;221(6):882-889. doi: 10.1093/infdis/jiz531. J Infect Dis. 2020. PMID: 31621854 Free PMC article.
Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV.
Sheahan TP, Sims AC, Leist SR, Schäfer A, Won J, Brown AJ, Montgomery SA, Hogg A, Babusis D, Clarke MO, Spahn JE, Bauer L, Sellers S, Porter D, Feng JY, Cihlar T, Jordan R, Denison MR, Baric RS. Sheahan TP, et al. Among authors: schafer a. Nat Commun. 2020 Jan 10;11(1):222. doi: 10.1038/s41467-019-13940-6. Nat Commun. 2020. PMID: 31924756 Free PMC article.
An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice.
Sheahan TP, Sims AC, Zhou S, Graham RL, Pruijssers AJ, Agostini ML, Leist SR, Schäfer A, Dinnon KH 3rd, Stevens LJ, Chappell JD, Lu X, Hughes TM, George AS, Hill CS, Montgomery SA, Brown AJ, Bluemling GR, Natchus MG, Saindane M, Kolykhalov AA, Painter G, Harcourt J, Tamin A, Thornburg NJ, Swanstrom R, Denison MR, Baric RS. Sheahan TP, et al. Among authors: schafer a. Sci Transl Med. 2020 Apr 29;12(541):eabb5883. doi: 10.1126/scitranslmed.abb5883. Epub 2020 Apr 6. Sci Transl Med. 2020. PMID: 32253226 Free PMC article.
1,748 results