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Prostanoid receptor subtypes involved in treprostinil-mediated vasodilation of rat pulmonary arteries and in treprostinil-mediated inhibition of collagen gene expression of human lung fibroblasts.
Corboz MR, Salvail W, Gagnon S, LaSala D, Laurent CE, Salvail D, Chen KJ, Cipolla D, Perkins WR, Chapman RW. Corboz MR, et al. Among authors: laurent ce. Prostaglandins Other Lipid Mediat. 2021 Feb;152:106486. doi: 10.1016/j.prostaglandins.2020.106486. Epub 2020 Oct 1. Prostaglandins Other Lipid Mediat. 2021. PMID: 33011365 Free article.
Preclinical Pharmacology and Pharmacokinetics of Inhaled Hexadecyl-Treprostinil (C16TR), a Pulmonary Vasodilator Prodrug.
Corboz MR, Li Z, Malinin V, Plaunt AJ, Konicek DM, Leifer FG, Chen KJ, Laurent CE, Yin H, Biernat MC, Salvail D, Zhuang J, Xu F, Curran A, Perkins WR, Chapman RW. Corboz MR, et al. Among authors: laurent ce. J Pharmacol Exp Ther. 2017 Dec;363(3):348-357. doi: 10.1124/jpet.117.242099. Epub 2017 Sep 13. J Pharmacol Exp Ther. 2017. PMID: 28904003
Inhaled hexadecyl-treprostinil provides pulmonary vasodilator activity at significantly lower plasma concentrations than infused treprostinil.
Chapman RW, Li Z, Corboz MR, Gauani H, Plaunt AJ, Konicek DM, Leifer FG, Laurent CE, Yin H, Salvail D, Dziak C, Perkins WR, Malinin V. Chapman RW, et al. Among authors: laurent ce. Pulm Pharmacol Ther. 2018 Apr;49:104-111. doi: 10.1016/j.pupt.2018.02.002. Epub 2018 Feb 5. Pulm Pharmacol Ther. 2018. PMID: 29421665 Free article.
The thromboxane receptor antagonist NTP42 promotes beneficial adaptation and preserves cardiac function in experimental models of right heart overload.
Mulvaney EP, Renzo F, Adão R, Dupre E, Bialesova L, Salvatore V, Reid HM, Conceição G, Grynblat J, Llucià-Valldeperas A, Michel JB, Brás-Silva C, Laurent CE, Howard LS, Montani D, Humbert M, Vonk Noordegraaf A, Perros F, Mendes-Ferreira P, Kinsella BT. Mulvaney EP, et al. Among authors: laurent ce. Front Cardiovasc Med. 2022 Dec 14;9:1063967. doi: 10.3389/fcvm.2022.1063967. eCollection 2022. Front Cardiovasc Med. 2022. PMID: 36588576 Free PMC article.
Evaluation of the effects of RP5063, a novel, multimodal, serotonin receptor modulator, as single-agent therapy and co-administrated with sildenafil, bosentan, and treprostinil in a monocrotaline-induced pulmonary arterial hypertension rat model.
Bhat L, Hawkinson J, Cantillon M, Reddy DG, Bhat SR, Laurent CE, Bouchard A, Biernat M, Salvail D. Bhat L, et al. Among authors: laurent ce. Eur J Pharmacol. 2018 May 15;827:159-166. doi: 10.1016/j.ejphar.2018.02.017. Epub 2018 Feb 14. Eur J Pharmacol. 2018. PMID: 29453947 Free article.
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