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Rational design of balanced dual-targeting antibiotics with limited resistance.
Nyerges A, Tomašič T, Durcik M, Revesz T, Szili P, Draskovits G, Bogar F, Skok Ž, Zidar N, Ilaš J, Zega A, Kikelj D, Daruka L, Kintses B, Vasarhelyi B, Foldesi I, Kata D, Welin M, Kimbung R, Focht D, Mašič LP, Pal C. Nyerges A, et al. PLoS Biol. 2020 Oct 5;18(10):e3000819. doi: 10.1371/journal.pbio.3000819. eCollection 2020 Oct. PLoS Biol. 2020. PMID: 33017402 Free PMC article.
A swapped genetic code prevents viral infections and gene transfer.
Nyerges A, Vinke S, Flynn R, Owen SV, Rand EA, Budnik B, Keen E, Narasimhan K, Marchand JA, Baas-Thomas M, Liu M, Chen K, Chiappino-Pepe A, Hu F, Baym M, Church GM. Nyerges A, et al. Nature. 2023 Mar;615(7953):720-727. doi: 10.1038/s41586-023-05824-z. Epub 2023 Mar 15. Nature. 2023. PMID: 36922599 Free PMC article.
Genome-Wide Abolishment of Mobile Genetic Elements Using Genome Shuffling and CRISPR/Cas-Assisted MAGE Allows the Efficient Stabilization of a Bacterial Chassis.
Umenhoffer K, Draskovits G, Nyerges Á, Karcagi I, Bogos B, Tímár E, Csörgő B, Herczeg R, Nagy I, Fehér T, Pál C, Pósfai G. Umenhoffer K, et al. Among authors: nyerges a. ACS Synth Biol. 2017 Aug 18;6(8):1471-1483. doi: 10.1021/acssynbio.6b00378. Epub 2017 Apr 26. ACS Synth Biol. 2017. PMID: 28426191
Phenotypic heterogeneity promotes adaptive evolution.
Bódi Z, Farkas Z, Nevozhay D, Kalapis D, Lázár V, Csörgő B, Nyerges Á, Szamecz B, Fekete G, Papp B, Araújo H, Oliveira JL, Moura G, Santos MAS, Székely T Jr, Balázsi G, Pál C. Bódi Z, et al. Among authors: nyerges a. PLoS Biol. 2017 May 9;15(5):e2000644. doi: 10.1371/journal.pbio.2000644. eCollection 2017 May. PLoS Biol. 2017. PMID: 28486496 Free PMC article.
New N-phenylpyrrolamide DNA gyrase B inhibitors: Optimization of efficacy and antibacterial activity.
Durcik M, Lovison D, Skok Ž, Durante Cruz C, Tammela P, Tomašič T, Benedetto Tiz D, Draskovits G, Nyerges Á, Pál C, Ilaš J, Peterlin Mašič L, Kikelj D, Zidar N. Durcik M, et al. Among authors: nyerges a. Eur J Med Chem. 2018 Jun 25;154:117-132. doi: 10.1016/j.ejmech.2018.05.011. Epub 2018 May 10. Eur J Med Chem. 2018. PMID: 29778894 Free PMC article.
61 results