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Favipiravir at high doses has potent antiviral activity in SARS-CoV-2-infected hamsters, whereas hydroxychloroquine lacks activity.
Kaptein SJF, Jacobs S, Langendries L, Seldeslachts L, Ter Horst S, Liesenborghs L, Hens B, Vergote V, Heylen E, Barthelemy K, Maas E, De Keyzer C, Bervoets L, Rymenants J, Van Buyten T, Zhang X, Abdelnabi R, Pang J, Williams R, Thibaut HJ, Dallmeier K, Boudewijns R, Wouters J, Augustijns P, Verougstraete N, Cawthorne C, Breuer J, Solas C, Weynand B, Annaert P, Spriet I, Vande Velde G, Neyts J, Rocha-Pereira J, Delang L. Kaptein SJF, et al. Proc Natl Acad Sci U S A. 2020 Oct 27;117(43):26955-26965. doi: 10.1073/pnas.2014441117. Epub 2020 Oct 9. Proc Natl Acad Sci U S A. 2020. PMID: 33037151 Free PMC article.
Favipiravir (T-705) inhibits in vitro norovirus replication.
Rocha-Pereira J, Jochmans D, Dallmeier K, Leyssen P, Nascimento MS, Neyts J. Rocha-Pereira J, et al. Biochem Biophys Res Commun. 2012 Aug 10;424(4):777-80. doi: 10.1016/j.bbrc.2012.07.034. Epub 2012 Jul 15. Biochem Biophys Res Commun. 2012. PMID: 22809499
Norovirus: targets and tools in antiviral drug discovery.
Rocha-Pereira J, Neyts J, Jochmans D. Rocha-Pereira J, et al. Biochem Pharmacol. 2014 Sep 1;91(1):1-11. doi: 10.1016/j.bcp.2014.05.021. Epub 2014 Jun 2. Biochem Pharmacol. 2014. PMID: 24893351 Free PMC article. Review.
Molecular chaperone Hsp90 is a therapeutic target for noroviruses.
Vashist S, Urena L, Gonzalez-Hernandez MB, Choi J, de Rougemont A, Rocha-Pereira J, Neyts J, Hwang S, Wobus CE, Goodfellow I. Vashist S, et al. J Virol. 2015 Jun;89(12):6352-63. doi: 10.1128/JVI.00315-15. Epub 2015 Apr 8. J Virol. 2015. PMID: 25855731 Free PMC article.
56 results