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Hepatocyte-intrinsic type I interferon signaling reprograms metabolism and reveals a novel compensatory mechanism of the tryptophan-kynurenine pathway in viral hepatitis.
Lercher A, Popa AM, Viczenczova C, Kosack L, Klavins K, Agerer B, Opitz CA, Lanz TV, Platten M, Bergthaler A. Lercher A, et al. Among authors: kosack l. PLoS Pathog. 2020 Oct 12;16(10):e1008973. doi: 10.1371/journal.ppat.1008973. eCollection 2020 Oct. PLoS Pathog. 2020. PMID: 33045014 Free PMC article.
Type I Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function.
Lercher A, Bhattacharya A, Popa AM, Caldera M, Schlapansky MF, Baazim H, Agerer B, Gürtl B, Kosack L, Májek P, Brunner JS, Vitko D, Pinter T, Genger JW, Orlova A, Pikor N, Reil D, Ozsvár-Kozma M, Kalinke U, Ludewig B, Moriggl R, Bennett KL, Menche J, Cheng PN, Schabbauer G, Trauner M, Klavins K, Bergthaler A. Lercher A, et al. Among authors: kosack l. Immunity. 2019 Dec 17;51(6):1074-1087.e9. doi: 10.1016/j.immuni.2019.10.014. Epub 2019 Nov 26. Immunity. 2019. PMID: 31784108 Free PMC article.
CD8+ T cells induce cachexia during chronic viral infection.
Baazim H, Schweiger M, Moschinger M, Xu H, Scherer T, Popa A, Gallage S, Ali A, Khamina K, Kosack L, Vilagos B, Smyth M, Lercher A, Friske J, Merkler D, Aderem A, Helbich TH, Heikenwälder M, Lang PA, Zechner R, Bergthaler A. Baazim H, et al. Among authors: kosack l. Nat Immunol. 2019 Jun;20(6):701-710. doi: 10.1038/s41590-019-0397-y. Epub 2019 May 20. Nat Immunol. 2019. PMID: 31110314 Free PMC article.
Characterization of host proteins interacting with the lymphocytic choriomeningitis virus L protein.
Khamina K, Lercher A, Caldera M, Schliehe C, Vilagos B, Sahin M, Kosack L, Bhattacharya A, Májek P, Stukalov A, Sacco R, James LC, Pinschewer DD, Bennett KL, Menche J, Bergthaler A. Khamina K, et al. Among authors: kosack l. PLoS Pathog. 2017 Dec 20;13(12):e1006758. doi: 10.1371/journal.ppat.1006758. eCollection 2017 Dec. PLoS Pathog. 2017. PMID: 29261807 Free PMC article.
Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage.
Bhattacharya A, Hegazy AN, Deigendesch N, Kosack L, Cupovic J, Kandasamy RK, Hildebrandt A, Merkler D, Kühl AA, Vilagos B, Schliehe C, Panse I, Khamina K, Baazim H, Arnold I, Flatz L, Xu HC, Lang PA, Aderem A, Takaoka A, Superti-Furga G, Colinge J, Ludewig B, Löhning M, Bergthaler A. Bhattacharya A, et al. Among authors: kosack l. Immunity. 2015 Nov 17;43(5):974-86. doi: 10.1016/j.immuni.2015.10.013. Immunity. 2015. PMID: 26588782 Free PMC article.
The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection.
Schliehe C, Flynn EK, Vilagos B, Richson U, Swaminanthan S, Bosnjak B, Bauer L, Kandasamy RK, Griesshammer IM, Kosack L, Schmitz F, Litvak V, Sissons J, Lercher A, Bhattacharya A, Khamina K, Trivett AL, Tessarollo L, Mesteri I, Hladik A, Merkler D, Kubicek S, Knapp S, Epstein MM, Symer DE, Aderem A, Bergthaler A. Schliehe C, et al. Among authors: kosack l. Nat Immunol. 2015 Jan;16(1):67-74. doi: 10.1038/ni.3046. Epub 2014 Nov 24. Nat Immunol. 2015. PMID: 25419628 Free PMC article.
The ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease.
Kosack L, Wingelhofer B, Popa A, Orlova A, Agerer B, Vilagos B, Majek P, Parapatics K, Lercher A, Ringler A, Klughammer J, Smyth M, Khamina K, Baazim H, de Araujo ED, Rosa DA, Park J, Tin G, Ahmar S, Gunning PT, Bock C, Siddle HV, Woods GM, Kubicek S, Murchison EP, Bennett KL, Moriggl R, Bergthaler A. Kosack L, et al. Cancer Cell. 2019 Jan 14;35(1):125-139.e9. doi: 10.1016/j.ccell.2018.11.018. Cancer Cell. 2019. PMID: 30645971 Free PMC article.
14 results