Summa V - Search Results

1

Optimization of linear and cyclic peptide inhibitors of KEAP1-NRF2 protein-protein interaction.

Colarusso S, De Simone D, Frattarelli T, Andreini M, Cerretani M, Missineo A, Moretti D, Tambone S, Kempf G, Augustin M, Steinbacher S, Munoz-Sanjuan I, Park L, Summa V, Tomei L, Bresciani A, Dominguez C, Toledo-Sherman L, Bianchi E. Colarusso S, et al. Among authors: summa v. Bioorg Med Chem. 2020 Nov 1;28(21):115738. doi: 10.1016/j.bmc.2020.115738. Epub 2020 Aug 30. Bioorg Med Chem. 2020. PMID: 33065433

2

Nirmatrelvir treatment of SARS-CoV-2-infected mice blunts antiviral adaptive immune responses.

Fumagalli V, Di Lucia P, Ravà M, Marotta D, Bono E, Grassi S, Donnici L, Cannalire R, Stefanelli I, Ferraro A, Esposito F, Pariani E, Inverso D, Montesano C, Delbue S, Perlman S, Tramontano E, De Francesco R, Summa V, Guidotti LG, Iannacone M. Fumagalli V, et al. Among authors: summa v. EMBO Mol Med. 2023 May 8;15(5):e17580. doi: 10.15252/emmm.202317580. Epub 2023 Mar 22. EMBO Mol Med. 2023. PMID: 36946379 Free PMC article.

3

Approaching a new era for hepatitis C virus therapy: inhibitors of the NS3-4A serine protease and the NS5B RNA-dependent RNA polymerase.

De Francesco R, Tomei L, Altamura S, Summa V, Migliaccio G. De Francesco R, et al. Among authors: summa v. Antiviral Res. 2003 Mar;58(1):1-16. doi: 10.1016/s0166-3542(03)00028-7. Antiviral Res. 2003. PMID: 12719002 Review.

4

Discovery of alpha,gamma-diketo acids as potent selective and reversible inhibitors of hepatitis C virus NS5b RNA-dependent RNA polymerase.

Summa V, Petrocchi A, Pace P, Matassa VG, De Francesco R, Altamura S, Tomei L, Koch U, Neuner P. Summa V, et al. J Med Chem. 2004 Jan 1;47(1):14-7. doi: 10.1021/jm0342109. J Med Chem. 2004. PMID: 14695815

5

The monoethyl ester of meconic acid is an active site inhibitor of HCV NS5B RNA-dependent RNA polymerase.

Pace P, Nizi E, Pacini B, Pesci S, Matassa V, De Francesco R, Altamura S, Summa V. Pace P, et al. Among authors: summa v. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3257-61. doi: 10.1016/j.bmcl.2004.03.087. Bioorg Med Chem Lett. 2004. PMID: 15149686

6

HCV NS5b RNA-dependent RNA polymerase inhibitors: from alpha,gamma-diketoacids to 4,5-dihydroxypyrimidine- or 3-methyl-5-hydroxypyrimidinonecarboxylic acids. Design and synthesis.

Summa V, Petrocchi A, Matassa VG, Taliani M, Laufer R, De Francesco R, Altamura S, Pace P. Summa V, et al. J Med Chem. 2004 Oct 21;47(22):5336-9. doi: 10.1021/jm0494669. J Med Chem. 2004. PMID: 15481971

7

Tetrazole thioacetanilides: potent non-nucleoside inhibitors of WT HIV reverse transcriptase and its K103N mutant.

Muraglia E, Kinzel OD, Laufer R, Miller MD, Moyer G, Munshi V, Orvieto F, Palumbi MC, Pescatore G, Rowley M, Williams PD, Summa V. Muraglia E, et al. Among authors: summa v. Bioorg Med Chem Lett. 2006 May 15;16(10):2748-52. doi: 10.1016/j.bmcl.2006.02.024. Epub 2006 Feb 28. Bioorg Med Chem Lett. 2006. PMID: 16503141

8

From dihydroxypyrimidine carboxylic acids to carboxamide HIV-1 integrase inhibitors: SAR around the amide moiety.

Petrocchi A, Koch U, Matassa VG, Pacini B, Stillmock KA, Summa V. Petrocchi A, et al. Among authors: summa v. Bioorg Med Chem Lett. 2007 Jan 15;17(2):350-3. doi: 10.1016/j.bmcl.2006.10.054. Epub 2006 Oct 25. Bioorg Med Chem Lett. 2007. PMID: 17107799

9

4,5-dihydroxypyrimidine carboxamides and N-alkyl-5-hydroxypyrimidinone carboxamides are potent, selective HIV integrase inhibitors with good pharmacokinetic profiles in preclinical species.

Summa V, Petrocchi A, Matassa VG, Gardelli C, Muraglia E, Rowley M, Paz OG, Laufer R, Monteagudo E, Pace P. Summa V, et al. J Med Chem. 2006 Nov 16;49(23):6646-9. doi: 10.1021/jm060854f. J Med Chem. 2006. PMID: 17154493

10

Dihydroxypyrimidine-4-carboxamides as novel potent and selective HIV integrase inhibitors.

Pace P, Di Francesco ME, Gardelli C, Harper S, Muraglia E, Nizi E, Orvieto F, Petrocchi A, Poma M, Rowley M, Scarpelli R, Laufer R, Gonzalez Paz O, Monteagudo E, Bonelli F, Hazuda D, Stillmock KA, Summa V. Pace P, et al. Among authors: summa v. J Med Chem. 2007 May 3;50(9):2225-39. doi: 10.1021/jm070027u. Epub 2007 Apr 12. J Med Chem. 2007. PMID: 17428043

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