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A single-cell RNA-sequencing training and analysis suite using the Galaxy framework.
Tekman M, Batut B, Ostrovsky A, Antoniewski C, Clements D, Ramirez F, Etherington GJ, Hotz HR, Scholtalbers J, Manning JR, Bellenger L, Doyle MA, Heydarian M, Huang N, Soranzo N, Moreno P, Mautner S, Papatheodorou I, Nekrutenko A, Taylor J, Blankenberg D, Backofen R, Grüning B. Tekman M, et al. Among authors: manning jr. Gigascience. 2020 Oct 20;9(10):giaa102. doi: 10.1093/gigascience/giaa102. Gigascience. 2020. PMID: 33079170 Free PMC article.
Expression Atlas update: from tissues to single cells.
Papatheodorou I, Moreno P, Manning J, Fuentes AM, George N, Fexova S, Fonseca NA, Füllgrabe A, Green M, Huang N, Huerta L, Iqbal H, Jianu M, Mohammed S, Zhao L, Jarnuczak AF, Jupp S, Marioni J, Meyer K, Petryszak R, Prada Medina CA, Talavera-López C, Teichmann S, Vizcaino JA, Brazma A. Papatheodorou I, et al. Nucleic Acids Res. 2020 Jan 8;48(D1):D77-D83. doi: 10.1093/nar/gkz947. Nucleic Acids Res. 2020. PMID: 31665515 Free PMC article.
User-friendly, scalable tools and workflows for single-cell RNA-seq analysis.
Moreno P, Huang N, Manning JR, Mohammed S, Solovyev A, Polanski K, Bacon W, Chazarra R, Talavera-López C, Doyle MA, Marnier G, Grüning B, Rasche H, George N, Fexova SK, Alibi M, Miao Z, Perez-Riverol Y, Haeussler M, Brazma A, Teichmann S, Meyer KB, Papatheodorou I. Moreno P, et al. Among authors: manning jr. Nat Methods. 2021 Apr;18(4):327-328. doi: 10.1038/s41592-021-01102-w. Nat Methods. 2021. PMID: 33782609 Free PMC article. No abstract available.
Expression Atlas update: gene and protein expression in multiple species.
Moreno P, Fexova S, George N, Manning JR, Miao Z, Mohammed S, Muñoz-Pomer A, Fullgrabe A, Bi Y, Bush N, Iqbal H, Kumbham U, Solovyev A, Zhao L, Prakash A, García-Seisdedos D, Kundu DJ, Wang S, Walzer M, Clarke L, Osumi-Sutherland D, Tello-Ruiz MK, Kumari S, Ware D, Eliasova J, Arends MJ, Nawijn MC, Meyer K, Burdett T, Marioni J, Teichmann S, Vizcaíno JA, Brazma A, Papatheodorou I. Moreno P, et al. Among authors: manning jr. Nucleic Acids Res. 2022 Jan 7;50(D1):D129-D140. doi: 10.1093/nar/gkab1030. Nucleic Acids Res. 2022. PMID: 34850121 Free PMC article.
A compendium of uniformly processed human gene expression and splicing quantitative trait loci.
Kerimov N, Hayhurst JD, Peikova K, Manning JR, Walter P, Kolberg L, Samoviča M, Sakthivel MP, Kuzmin I, Trevanion SJ, Burdett T, Jupp S, Parkinson H, Papatheodorou I, Yates AD, Zerbino DR, Alasoo K. Kerimov N, et al. Among authors: manning jr. Nat Genet. 2021 Sep;53(9):1290-1299. doi: 10.1038/s41588-021-00924-w. Epub 2021 Sep 6. Nat Genet. 2021. PMID: 34493866 Free PMC article.
Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly.
Li H, Janssens J, De Waegeneer M, Kolluru SS, Davie K, Gardeux V, Saelens W, David FPA, Brbić M, Spanier K, Leskovec J, McLaughlin CN, Xie Q, Jones RC, Brueckner K, Shim J, Tattikota SG, Schnorrer F, Rust K, Nystul TG, Carvalho-Santos Z, Ribeiro C, Pal S, Mahadevaraju S, Przytycka TM, Allen AM, Goodwin SF, Berry CW, Fuller MT, White-Cooper H, Matunis EL, DiNardo S, Galenza A, O'Brien LE, Dow JAT; FCA Consortium§; Jasper H, Oliver B, Perrimon N, Deplancke B, Quake SR, Luo L, Aerts S, Agarwal D, Ahmed-Braimah Y, Arbeitman M, Ariss MM, Augsburger J, Ayush K, Baker CC, Banisch T, Birker K, Bodmer R, Bolival B, Brantley SE, Brill JA, Brown NC, Buehner NA, Cai XT, Cardoso-Figueiredo R, Casares F, Chang A, Clandinin TR, Crasta S, Desplan C, Detweiler AM, Dhakan DB, Donà E, Engert S, Floc'hlay S, George N, González-Segarra AJ, Groves AK, Gumbin S, Guo Y, Harris DE, Heifetz Y, Holtz SL, Horns F, Hudry B, Hung RJ, Jan YN, Jaszczak JS, Jefferis GSXE, Karkanias J, Karr TL, Katheder NS, Kezos J, Kim AA, Kim SK, Kockel L, Konstantinides N, Kornberg TB, Krause HM, Labott AT, Laturney M, Lehmann R, Leinwand S, Li J, Li JSS, Li K, Li K, Li L, Li T, Litovchenko M, Liu HH, Liu Y, Lu TC, Manning J, M… See abstract for full author list ➔ Li H, et al. Science. 2022 Mar 4;375(6584):eabk2432. doi: 10.1126/science.abk2432. Epub 2022 Mar 4. Science. 2022. PMID: 35239393 Free PMC article.
Applications of single-cell RNA sequencing in drug discovery and development.
Van de Sande B, Lee JS, Mutasa-Gottgens E, Naughton B, Bacon W, Manning J, Wang Y, Pollard J, Mendez M, Hill J, Kumar N, Cao X, Chen X, Khaladkar M, Wen J, Leach A, Ferran E. Van de Sande B, et al. Nat Rev Drug Discov. 2023 Jun;22(6):496-520. doi: 10.1038/s41573-023-00688-4. Epub 2023 Apr 28. Nat Rev Drug Discov. 2023. PMID: 37117846 Free PMC article. Review.
Discovery and Optimization of First-in-Class Molecular Glue Degraders of the WIZ Transcription Factor for Fetal Hemoglobin Induction to Treat Sickle Cell Disease.
Kerrigan JR, Thomsen NM, Cernijenko A, Kochanek SE, Dewhurst J, O'Brien G, Ware NF, Sanchez CC, Manning JR, Ma X, Ornelas E, Savage NA, Partridge JR, Patterson AW, Lam P, Dales NA, Bonazzi S, Borikar S, Hinman AE, Ting PY. Kerrigan JR, et al. Among authors: manning jr. J Med Chem. 2024 Nov 28;67(22):20682-20694. doi: 10.1021/acs.jmedchem.4c02251. Epub 2024 Nov 14. J Med Chem. 2024. PMID: 39541509
268 results