Kong LR - Search Results

1

Targeting Metabolism in Cancer Cells and the Tumour Microenvironment for Cancer Therapy.

Li J, Eu JQ, Kong LR, Wang L, Lim YC, Goh BC, Wong ALA. Li J, et al. Among authors: kong lr. Molecules. 2020 Oct 20;25(20):4831. doi: 10.3390/molecules25204831. Molecules. 2020. PMID: 33092283 Free PMC article. Review.

2

Phase I and biomarker study of OPB-51602, a novel signal transducer and activator of transcription (STAT) 3 inhibitor, in patients with refractory solid malignancies.

Wong AL, Soo RA, Tan DS, Lee SC, Lim JS, Marban PC, Kong LR, Lee YJ, Wang LZ, Thuya WL, Soong R, Yee MQ, Chin TM, Cordero MT, Asuncion BR, Pang B, Pervaiz S, Hirpara JL, Sinha A, Xu WW, Yuasa M, Tsunoda T, Motoyama M, Yamauchi T, Goh BC. Wong AL, et al. Among authors: kong lr. Ann Oncol. 2015 May;26(5):998-1005. doi: 10.1093/annonc/mdv026. Epub 2015 Jan 21. Ann Oncol. 2015. PMID: 25609248 Free article. Clinical Trial.

3

MEK Inhibition Overcomes Cisplatin Resistance Conferred by SOS/MAPK Pathway Activation in Squamous Cell Carcinoma.

Kong LR, Chua KN, Sim WJ, Ng HC, Bi C, Ho J, Nga ME, Pang YH, Ong WR, Soo RA, Huynh H, Chng WJ, Thiery JP, Goh BC. Kong LR, et al. Mol Cancer Ther. 2015 Jul;14(7):1750-60. doi: 10.1158/1535-7163.MCT-15-0062. Epub 2015 May 4. Mol Cancer Ther. 2015. PMID: 25939760

4

Combinatorial treatment using targeted MEK and SRC inhibitors synergistically abrogates tumor cell growth and induces mesenchymal-epithelial transition in non-small-cell lung carcinoma.

Chua KN, Kong LR, Sim WJ, Ng HC, Ong WR, Thiery JP, Huynh H, Goh BC. Chua KN, et al. Among authors: kong lr. Oncotarget. 2015 Oct 6;6(30):29991-30005. doi: 10.18632/oncotarget.5031. Oncotarget. 2015. PMID: 26358373 Free PMC article.

5

A novel combinatorial strategy using Seliciclib(®) and Belinostat(®) for eradication of non-small cell lung cancer via apoptosis induction and BID activation.

Ong PS, Wang L, Chia DM, Seah JY, Kong LR, Thuya WL, Chinnathambi A, Lau JY, Wong AL, Yong WP, Yang D, Ho PC, Sethi G, Goh BC. Ong PS, et al. Among authors: kong lr. Cancer Lett. 2016 Oct 10;381(1):49-57. doi: 10.1016/j.canlet.2016.07.023. Epub 2016 Jul 25. Cancer Lett. 2016. PMID: 27461583

6

Pan-HDAC inhibition by panobinostat mediates chemosensitization to carboplatin in non-small cell lung cancer via attenuation of EGFR signaling.

Wang L, Syn NL, Subhash VV, Any Y, Thuya WL, Cheow ESH, Kong L, Yu F, Peethala PC, Wong AL, Laljibhai HJ, Chinnathambi A, Ong PS, Ho PC, Sethi G, Yong WP, Goh BC. Wang L, et al. Cancer Lett. 2018 Mar 28;417:152-160. doi: 10.1016/j.canlet.2017.12.030. Epub 2018 Jan 4. Cancer Lett. 2018. PMID: 29306016

7

Pan-CDK inhibition augments cisplatin lethality in nasopharyngeal carcinoma cell lines and xenograft models.

Syn NL, Lim PL, Kong LR, Wang L, Wong AL, Lim CM, Loh TKS, Siemeister G, Goh BC, Hsieh WS. Syn NL, et al. Among authors: kong lr. Signal Transduct Target Ther. 2018 Apr 13;3:9. doi: 10.1038/s41392-018-0010-0. eCollection 2018. Signal Transduct Target Ther. 2018. PMID: 29666673 Free PMC article.

8

Metabolic reprogramming of oncogene-addicted cancer cells to OXPHOS as a mechanism of drug resistance.

Hirpara J, Eu JQ, Tan JKM, Wong AL, Clement MV, Kong LR, Ohi N, Tsunoda T, Qu J, Goh BC, Pervaiz S. Hirpara J, et al. Among authors: kong lr. Redox Biol. 2019 Jul;25:101076. doi: 10.1016/j.redox.2018.101076. Epub 2018 Dec 17. Redox Biol. 2019. PMID: 30642723 Free PMC article.

9

A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma.

Kong LR, Mohamed Salleh NAB, Ong RW, Tan TZ, Syn NL, Goh RM, Fhu CW, Tan DSW, Iyer NG, Kannan S, Verma CS, Lim YC, Soo R, Ho J, Huang Y, Lim JSJ, Yan BJ, Nga ME, Lim SG, Koeffler HP, Lee SC, Kappei D, Hung HT, Goh BC. Kong LR, et al. Nat Commun. 2020 Mar 25;11(1):1556. doi: 10.1038/s41467-020-15318-5. Nat Commun. 2020. PMID: 32214092 Free PMC article.

10

Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation.

Kong LR, Ong RW, Tan TZ, Mohamed Salleh NAB, Thangavelu M, Chan JV, Koh LYJ, Periyasamy G, Lau JA, Le TBU, Wang L, Lee M, Kannan S, Verma CS, Lim CM, Chng WJ, Lane DP, Venkitaraman A, Hung HT, Cheok CF, Goh BC. Kong LR, et al. Nat Commun. 2020 Apr 29;11(1):2086. doi: 10.1038/s41467-020-15608-y. Nat Commun. 2020. PMID: 32350249 Free PMC article.

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