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Page 1
NRF2 activation by reversible KEAP1 binding induces the antioxidant response in primary neurons and astrocytes of a Huntington's disease mouse model.
Moretti D, Tambone S, Cerretani M, Fezzardi P, Missineo A, Sherman LT, Munoz-Sajuan I, Harper S, Dominquez C, Pacifici R, Tomei L, Park L, Bresciani A. Moretti D, et al. Among authors: bresciani a. Free Radic Biol Med. 2021 Jan;162:243-254. doi: 10.1016/j.freeradbiomed.2020.10.022. Epub 2020 Oct 21. Free Radic Biol Med. 2021. PMID: 33096251
Nuclear factor (erythroid-derived 2)-like 2 (NRF2) drug discovery: Biochemical toolbox to develop NRF2 activators by reversible binding of Kelch-like ECH-associated protein 1 (KEAP1).
Bresciani A, Missineo A, Gallo M, Cerretani M, Fezzardi P, Tomei L, Cicero DO, Altamura S, Santoprete A, Ingenito R, Bianchi E, Pacifici R, Dominguez C, Munoz-Sanjuan I, Harper S, Toledo-Sherman L, Park LC. Bresciani A, et al. Arch Biochem Biophys. 2017 Oct 1;631:31-41. doi: 10.1016/j.abb.2017.08.003. Epub 2017 Aug 8. Arch Biochem Biophys. 2017. PMID: 28801166 Review.
Discovery by organism based high-throughput screening of new multi-stage compounds affecting Schistosoma mansoni viability, egg formation and production.
Guidi A, Lalli C, Gimmelli R, Nizi E, Andreini M, Gennari N, Saccoccia F, Harper S, Bresciani A, Ruberti G. Guidi A, et al. Among authors: bresciani a. PLoS Negl Trop Dis. 2017 Oct 6;11(10):e0005994. doi: 10.1371/journal.pntd.0005994. eCollection 2017 Oct. PLoS Negl Trop Dis. 2017. PMID: 28985236 Free PMC article.
Identification and binding mode of a novel Leishmania Trypanothione reductase inhibitor from high throughput screening.
Turcano L, Torrente E, Missineo A, Andreini M, Gramiccia M, Di Muccio T, Genovese I, Fiorillo A, Harper S, Bresciani A, Colotti G, Ilari A. Turcano L, et al. Among authors: bresciani a. PLoS Negl Trop Dis. 2018 Nov 26;12(11):e0006969. doi: 10.1371/journal.pntd.0006969. eCollection 2018 Nov. PLoS Negl Trop Dis. 2018. PMID: 30475811 Free PMC article.
Janus effect of glucocorticoids on differentiation of muscle fibro/adipogenic progenitors.
Cerquone Perpetuini A, Giuliani G, Reggio A, Cerretani M, Santoriello M, Stefanelli R, Palma A, Vumbaca S, Harper S, Castagnoli L, Bresciani A, Cesareni G. Cerquone Perpetuini A, et al. Among authors: bresciani a. Sci Rep. 2020 Mar 24;10(1):5363. doi: 10.1038/s41598-020-62194-6. Sci Rep. 2020. PMID: 32210313 Free PMC article.
Adipogenesis of skeletal muscle fibro/adipogenic progenitors is affected by the WNT5a/GSK3/β-catenin axis.
Reggio A, Rosina M, Palma A, Cerquone Perpetuini A, Petrilli LL, Gargioli C, Fuoco C, Micarelli E, Giuliani G, Cerretani M, Bresciani A, Sacco F, Castagnoli L, Cesareni G. Reggio A, et al. Among authors: bresciani a. Cell Death Differ. 2020 Oct;27(10):2921-2941. doi: 10.1038/s41418-020-0551-y. Epub 2020 May 7. Cell Death Differ. 2020. PMID: 32382110 Free PMC article.
108 results