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Cell surface-tethered IL-12 repolarizes the tumor immune microenvironment to enhance the efficacy of adoptive T cell therapy.
Jones DS 2nd, Nardozzi JD, Sackton KL, Ahmad G, Christensen E, Ringgaard L, Chang DK, Jaehger DE, Konakondla JV, Wiinberg M, Stokes KL, Pratama A, Sauer K, Andresen TL. Jones DS 2nd, et al. Among authors: andresen tl. Sci Adv. 2022 Apr 29;8(17):eabi8075. doi: 10.1126/sciadv.abi8075. Epub 2022 Apr 27. Sci Adv. 2022. PMID: 35476449 Free PMC article.
An in situ depot for the sustained release of a TLR7/8 agonist in combination with a TGFβ inhibitor promotes anti-tumor immune responses.
Jensen SB, Jæhger DE, Serrano-Chávez E, Halldórsdóttir HR, Engel TB, Jørgensen JS, Björgvinsdóttir UJ, Kostrikov S, Scheeper MJ, Ringgaard L, Bruun LM, Stavnsbjerg C, Christensen E, Bak M, Thuroczy J, Balogh L, Jensen ATI, Melander F, Kjaer A, Henriksen JR, Hansen AE, Andresen TL. Jensen SB, et al. Among authors: andresen tl. Nat Commun. 2024 Sep 3;15(1):7687. doi: 10.1038/s41467-024-50967-w. Nat Commun. 2024. PMID: 39227589 Free PMC article.
228 results