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Page 1
Metabolic reprogramming of donor T cells enhances graft-versus-leukemia effects in mice and humans.
Uhl FM, Chen S, O'Sullivan D, Edwards-Hicks J, Richter G, Haring E, Andrieux G, Halbach S, Apostolova P, Büscher J, Duquesne S, Melchinger W, Sauer B, Shoumariyeh K, Schmitt-Graeff A, Kreutz M, Lübbert M, Duyster J, Brummer T, Boerries M, Madl T, Blazar BR, Groß O, Pearce EL, Zeiser R. Uhl FM, et al. Sci Transl Med. 2020 Oct 28;12(567):eabb8969. doi: 10.1126/scitranslmed.abb8969. Sci Transl Med. 2020. PMID: 33115954 Free PMC article.
Activation loop phosphorylation regulates B-Raf in vivo and transformation by B-Raf mutants.
Köhler M, Röring M, Schorch B, Heilmann K, Stickel N, Fiala GJ, Schmitt LC, Braun S, Ehrenfeld S, Uhl FM, Kaltenbacher T, Weinberg F, Herzog S, Zeiser R, Schamel WW, Jumaa H, Brummer T. Köhler M, et al. Among authors: uhl fm. EMBO J. 2016 Jan 18;35(2):143-61. doi: 10.15252/embj.201592097. Epub 2015 Dec 10. EMBO J. 2016. PMID: 26657898 Free PMC article.
The Atypical Kinase RIOK1 Promotes Tumor Growth and Invasive Behavior.
Weinberg F, Reischmann N, Fauth L, Taromi S, Mastroianni J, Köhler M, Halbach S, Becker AC, Deng N, Schmitz T, Uhl FM, Herbener N, Riedel B, Beier F, Swarbrick A, Lassmann S, Dengjel J, Zeiser R, Brummer T. Weinberg F, et al. Among authors: uhl fm. EBioMedicine. 2017 Jun;20:79-97. doi: 10.1016/j.ebiom.2017.04.015. Epub 2017 Apr 12. EBioMedicine. 2017. PMID: 28499923 Free PMC article.
B-Raf deficiency impairs tumor initiation and progression in a murine breast cancer model.
Köhler M, Ehrenfeld S, Halbach S, Lauinger M, Burk U, Reischmann N, Cheng S, Spohr C, Uhl FM, Köhler N, Ringwald K, Braun S, Peters C, Zeiser R, Reinheckel T, Brummer T. Köhler M, et al. Among authors: uhl fm. Oncogene. 2019 Feb;38(8):1324-1339. doi: 10.1038/s41388-018-0663-8. Epub 2019 Jan 18. Oncogene. 2019. PMID: 30659267
Gab2 is Essential for Transformation by FLT3-ITD in Acute Myeloid Leukemia.
Sies K, Spohr C, Gründer A, Todorova R, Uhl FM, Huber J, Zeiser R, Pahl HL, Becker H, Aumann K, Brummer T, Halbach S. Sies K, et al. Among authors: uhl fm. Hemasphere. 2019 Feb 22;3(2):e184. doi: 10.1097/HS9.0000000000000184. eCollection 2019 Apr. Hemasphere. 2019. PMID: 31723823 Free PMC article. No abstract available.
Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation.
Hamarsheh S, Osswald L, Saller BS, Unger S, De Feo D, Vinnakota JM, Konantz M, Uhl FM, Becker H, Lübbert M, Shoumariyeh K, Schürch C, Andrieux G, Venhoff N, Schmitt-Graeff A, Duquesne S, Pfeifer D, Cooper MA, Lengerke C, Boerries M, Duyster J, Niemeyer CM, Erlacher M, Blazar BR, Becher B, Groß O, Brummer T, Zeiser R. Hamarsheh S, et al. Among authors: uhl fm. Nat Commun. 2020 Apr 3;11(1):1659. doi: 10.1038/s41467-020-15497-1. Nat Commun. 2020. PMID: 32246016 Free PMC article.
Bile acids regulate intestinal antigen presentation and reduce graft-versus-host disease without impairing the graft-versus-leukemia effect.
Haring E, Uhl FM, Andrieux G, Proietti M, Bulashevska A, Sauer B, Braun LM, de Vega Gomez E, Esser PR, Martin SF, Pfeifer D, Follo M, Schmitt-Graeff A, Buescher J, Duyster J, Grimbacher B, Boerries M, Pearce EL, Zeiser R, Apostolova P. Haring E, et al. Among authors: uhl fm. Haematologica. 2021 Aug 1;106(8):2131-2146. doi: 10.3324/haematol.2019.242990. Haematologica. 2021. PMID: 32675222 Free PMC article.
Metabolic conditioning of CD8+ effector T cells for adoptive cell therapy.
Klein Geltink RI, Edwards-Hicks J, Apostolova P, O'Sullivan D, Sanin DE, Patterson AE, Puleston DJ, Ligthart NAM, Buescher JM, Grzes KM, Kabat AM, Stanczak M, Curtis JD, Hässler F, Uhl FM, Fabri M, Zeiser R, Pearce EJ, Pearce EL. Klein Geltink RI, et al. Among authors: uhl fm. Nat Metab. 2020 Aug;2(8):703-716. doi: 10.1038/s42255-020-0256-z. Epub 2020 Aug 3. Nat Metab. 2020. PMID: 32747793 Free PMC article.
16 results