Kokotos G - Search Results

1

Saturated Hydroxy Fatty Acids Exhibit a Cell Growth Inhibitory Activity and Suppress the Cytokine-Induced β-Cell Apoptosis.

Kokotou MG, Kokotos AC, Gkikas D, Mountanea OG, Mantzourani C, Almutairi A, Lei X, Ramanadham S, Politis PK, Kokotos G. Kokotou MG, et al. Among authors: kokotos ac, kokotos g. J Med Chem. 2020 Nov 12;63(21):12666-12681. doi: 10.1021/acs.jmedchem.0c00844. Epub 2020 Oct 30. J Med Chem. 2020. PMID: 33124824

2

Study of aminoglycoside-nucleic acid interactions by an HPLC method.

Constantinou-Kokotou T, Karikas G, Kokotos G. Constantinou-Kokotou T, et al. Among authors: kokotos g. Bioorg Med Chem Lett. 2001 Apr 23;11(8):1015-8. doi: 10.1016/s0960-894x(01)00115-9. Bioorg Med Chem Lett. 2001. PMID: 11327578

3

Inhibition of group IVA cytosolic phospholipase A2 by novel 2-oxoamides in vitro, in cells, and in vivo.

Kokotos G, Six DA, Loukas V, Smith T, Constantinou-Kokotou V, Hadjipavlou-Litina D, Kotsovolou S, Chiou A, Beltzner CC, Dennis EA. Kokotos G, et al. J Med Chem. 2004 Jul 1;47(14):3615-28. doi: 10.1021/jm030485c. J Med Chem. 2004. PMID: 15214789

We previously reported the discovery of novel 2-oxoamides that inhibit GIVA PLA(2) [Kokotos, G.; et al. J. Med. Chem. 2002, 45, 2891-2893]. In the present work, we have further explored this class of inhibitors and found that the 2-oxoamide functionality is more pot …

We previously reported the discovery of novel 2-oxoamides that inhibit GIVA PLA(2) [Kokotos, G.; et al. J. Med. Chem. 2002, 45 …

4

Structure-activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A(2) enzymes.

Antonopoulou G, Barbayianni E, Magrioti V, Cotton N, Stephens D, Constantinou-Kokotou V, Dennis EA, Kokotos G. Antonopoulou G, et al. Among authors: kokotos g. Bioorg Med Chem. 2008 Dec 15;16(24):10257-69. doi: 10.1016/j.bmc.2008.10.046. Epub 2008 Nov 1. Bioorg Med Chem. 2008. PMID: 18993078 Free PMC article.

5

Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes.

Baskakis C, Magrioti V, Cotton N, Stephens D, Constantinou-Kokotou V, Dennis EA, Kokotos G. Baskakis C, et al. Among authors: kokotos g. J Med Chem. 2008 Dec 25;51(24):8027-37. doi: 10.1021/jm800649q. J Med Chem. 2008. PMID: 19053783 Free PMC article.

6

2-Oxoamide inhibitors of phospholipase A2 activity and cellular arachidonate release based on dipeptides and pseudodipeptides.

Barbayianni E, Stephens D, Grkovich A, Magrioti V, Hsu YH, Dolatzas P, Kalogiannidis D, Dennis EA, Kokotos G. Barbayianni E, et al. Among authors: kokotos g. Bioorg Med Chem. 2009 Jul 1;17(13):4833-43. doi: 10.1016/j.bmc.2009.03.069. Epub 2009 May 3. Bioorg Med Chem. 2009. PMID: 19443224 Free PMC article.

7

Inhibition of secreted phospholipases A₂ by 2-oxoamides based on α-amino acids: Synthesis, in vitro evaluation and molecular docking calculations.

Mouchlis VD, Magrioti V, Barbayianni E, Cermak N, Oslund RC, Mavromoustakos TM, Gelb MH, Kokotos G. Mouchlis VD, et al. Among authors: kokotos g. Bioorg Med Chem. 2011 Jan 15;19(2):735-43. doi: 10.1016/j.bmc.2010.12.030. Epub 2010 Dec 16. Bioorg Med Chem. 2011. PMID: 21216150 Free PMC article.

8

New potent and selective polyfluoroalkyl ketone inhibitors of GVIA calcium-independent phospholipase A2.

Magrioti V, Nikolaou A, Smyrniotou A, Shah I, Constantinou-Kokotou V, Dennis EA, Kokotos G. Magrioti V, et al. Among authors: kokotos g. Bioorg Med Chem. 2013 Sep 15;21(18):5823-9. doi: 10.1016/j.bmc.2013.07.010. Epub 2013 Jul 16. Bioorg Med Chem. 2013. PMID: 23916152 Free PMC article.

9

Characterization of FKGK18 as inhibitor of group VIA Ca2+-independent phospholipase A2 (iPLA2β): candidate drug for preventing beta-cell apoptosis and diabetes.

Ali T, Kokotos G, Magrioti V, Bone RN, Mobley JA, Hancock W, Ramanadham S. Ali T, et al. Among authors: kokotos g. PLoS One. 2013 Aug 20;8(8):e71748. doi: 10.1371/journal.pone.0071748. eCollection 2013. PLoS One. 2013. PMID: 23977134 Free PMC article.

10

Inhibition of group IVA cytosolic phospholipase A2 by thiazolyl ketones in vitro, ex vivo, and in vivo.

Kokotos G, Feuerherm AJ, Barbayianni E, Shah I, Sæther M, Magrioti V, Nguyen T, Constantinou-Kokotou V, Dennis EA, Johansen B. Kokotos G, et al. J Med Chem. 2014 Sep 25;57(18):7523-35. doi: 10.1021/jm500192s. Epub 2014 Sep 3. J Med Chem. 2014. PMID: 25152071 Free article.

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