Kokotou MG - Search Results

1

Saturated Hydroxy Fatty Acids Exhibit a Cell Growth Inhibitory Activity and Suppress the Cytokine-Induced β-Cell Apoptosis.

Kokotou MG, Kokotos AC, Gkikas D, Mountanea OG, Mantzourani C, Almutairi A, Lei X, Ramanadham S, Politis PK, Kokotos G. Kokotou MG, et al. J Med Chem. 2020 Nov 12;63(21):12666-12681. doi: 10.1021/acs.jmedchem.0c00844. Epub 2020 Oct 30. J Med Chem. 2020. PMID: 33124824

2

Inhibition of Ca2+-independent phospholipase A2β (iPLA2β) ameliorates islet infiltration and incidence of diabetes in NOD mice.

Bone RN, Gai Y, Magrioti V, Kokotou MG, Ali T, Lei X, Tse HM, Kokotos G, Ramanadham S. Bone RN, et al. Among authors: kokotou mg. Diabetes. 2015 Feb;64(2):541-54. doi: 10.2337/db14-0097. Epub 2014 Sep 11. Diabetes. 2015. PMID: 25213337 Free PMC article.

3

Development of Potent and Selective Inhibitors for Group VIA Calcium-Independent Phospholipase A2 Guided by Molecular Dynamics and Structure-Activity Relationships.

Mouchlis VD, Limnios D, Kokotou MG, Barbayianni E, Kokotos G, McCammon JA, Dennis EA. Mouchlis VD, et al. Among authors: kokotou mg. J Med Chem. 2016 May 12;59(9):4403-14. doi: 10.1021/acs.jmedchem.6b00377. Epub 2016 Apr 28. J Med Chem. 2016. PMID: 27087127 Free PMC article.

4

2-Oxoamide inhibitors of cytosolic group IVA phospholipase A2 with reduced lipophilicity.

Antonopoulou G, Magrioti V, Kokotou MG, Nikolaou A, Barbayianni E, Mouchlis VD, Dennis EA, Kokotos G. Antonopoulou G, et al. Among authors: kokotou mg. Bioorg Med Chem. 2016 Oct 1;24(19):4544-4554. doi: 10.1016/j.bmc.2016.07.057. Epub 2016 Jul 27. Bioorg Med Chem. 2016. PMID: 27522578 Free PMC article.

5

Inhibitors of phospholipase A₂ and their therapeutic potential: an update on patents (2012-2016).

Kokotou MG, Limnios D, Nikolaou A, Psarra A, Kokotos G. Kokotou MG, et al. Expert Opin Ther Pat. 2017 Feb;27(2):217-225. doi: 10.1080/13543776.2017.1246540. Epub 2016 Oct 22. Expert Opin Ther Pat. 2017. PMID: 27718763 Review.

6

2-Oxoamides based on dipeptides as selective calcium-independent phospholipase A₂ inhibitors.

Smyrniotou A, Kokotou MG, Mouchlis VD, Barbayianni E, Kokotos G, Dennis EA, Constantinou-Kokotou V. Smyrniotou A, et al. Among authors: kokotou mg. Bioorg Med Chem. 2017 Feb 1;25(3):926-940. doi: 10.1016/j.bmc.2016.12.007. Epub 2016 Dec 8. Bioorg Med Chem. 2017. PMID: 28034646 Free PMC article.

7

Autotaxin inhibitors: a patent review (2012-2016).

Nikolaou A, Kokotou MG, Limnios D, Psarra A, Kokotos G. Nikolaou A, et al. Among authors: kokotou mg. Expert Opin Ther Pat. 2017 Jul;27(7):815-829. doi: 10.1080/13543776.2017.1323331. Epub 2017 May 9. Expert Opin Ther Pat. 2017. PMID: 28447479 Review.

8

Microsomal prostaglandin E₂ synthase-1 inhibitors: a patent review.

Psarra A, Nikolaou A, Kokotou MG, Limnios D, Kokotos G. Psarra A, et al. Among authors: kokotou mg. Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059. doi: 10.1080/13543776.2017.1344218. Epub 2017 Jun 26. Expert Opin Ther Pat. 2017. PMID: 28627961 Review.

9

2-Oxoesters: A Novel Class of Potent and Selective Inhibitors of Cytosolic Group IVA Phospholipase A₂.

Kokotou MG, Galiatsatou G, Magrioti V, Koutoulogenis G, Barbayianni E, Limnios D, Mouchlis VD, Satpathy B, Navratil A, Dennis EA, Kokotos G. Kokotou MG, et al. Sci Rep. 2017 Aug 1;7(1):7025. doi: 10.1038/s41598-017-07330-5. Sci Rep. 2017. PMID: 28765606 Free PMC article.

10

Hydroxamic Acids Constitute a Novel Class of Autotaxin Inhibitors that Exhibit in Vivo Efficacy in a Pulmonary Fibrosis Model.

Nikolaou A, Ninou I, Kokotou MG, Kaffe E, Afantitis A, Aidinis V, Kokotos G. Nikolaou A, et al. Among authors: kokotou mg. J Med Chem. 2018 Apr 26;61(8):3697-3711. doi: 10.1021/acs.jmedchem.8b00232. Epub 2018 Apr 18. J Med Chem. 2018. PMID: 29620892

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