Lei X - Search Results

1

Saturated Hydroxy Fatty Acids Exhibit a Cell Growth Inhibitory Activity and Suppress the Cytokine-Induced β-Cell Apoptosis.

Kokotou MG, Kokotos AC, Gkikas D, Mountanea OG, Mantzourani C, Almutairi A, Lei X, Ramanadham S, Politis PK, Kokotos G. Kokotou MG, et al. Among authors: lei x. J Med Chem. 2020 Nov 12;63(21):12666-12681. doi: 10.1021/acs.jmedchem.0c00844. Epub 2020 Oct 30. J Med Chem. 2020. PMID: 33124824

2

Attenuated free cholesterol loading-induced apoptosis but preserved phospholipid composition of peritoneal macrophages from mice that do not express group VIA phospholipase A2.

Bao S, Li Y, Lei X, Wohltmann M, Jin W, Bohrer A, Semenkovich CF, Ramanadham S, Tabas I, Turk J. Bao S, et al. Among authors: lei x. J Biol Chem. 2007 Sep 14;282(37):27100-27114. doi: 10.1074/jbc.M701316200. Epub 2007 Jul 12. J Biol Chem. 2007. PMID: 17627946 Free PMC article.

3

The group VIA calcium-independent phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase.

Lei X, Zhang S, Bohrer A, Bao S, Song H, Ramanadham S. Lei X, et al. Biochemistry. 2007 Sep 4;46(35):10170-85. doi: 10.1021/bi700017z. Epub 2007 Aug 9. Biochemistry. 2007. PMID: 17685585 Free PMC article.

4

Calcium-independent phospholipase A2 (iPLA2 beta)-mediated ceramide generation plays a key role in the cross-talk between the endoplasmic reticulum (ER) and mitochondria during ER stress-induced insulin-secreting cell apoptosis.

Lei X, Zhang S, Bohrer A, Ramanadham S. Lei X, et al. J Biol Chem. 2008 Dec 12;283(50):34819-32. doi: 10.1074/jbc.M807409200. Epub 2008 Oct 20. J Biol Chem. 2008. PMID: 18936091 Free PMC article.

5

Protease inhibitors used in the treatment of HIV+ induce beta-cell apoptosis via the mitochondrial pathway and compromise insulin secretion.

Zhang S, Carper MJ, Lei X, Cade WT, Yarasheski KE, Ramanadham S. Zhang S, et al. Among authors: lei x. Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E925-35. doi: 10.1152/ajpendo.90445.2008. Epub 2009 Feb 10. Am J Physiol Endocrinol Metab. 2009. PMID: 19208856 Free PMC article.

6

Spontaneous development of endoplasmic reticulum stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase A2 expression: a role for regulation by SREBP-1.

Lei X, Zhang S, Barbour SE, Bohrer A, Ford EL, Koizumi A, Papa FR, Ramanadham S. Lei X, et al. J Biol Chem. 2010 Feb 26;285(9):6693-705. doi: 10.1074/jbc.M109.084293. Epub 2009 Dec 23. J Biol Chem. 2010. PMID: 20032468 Free PMC article.

7

Group VIA Ca2+-independent phospholipase A2 (iPLA2beta) and its role in beta-cell programmed cell death.

Lei X, Barbour SE, Ramanadham S. Lei X, et al. Biochimie. 2010 Jun;92(6):627-37. doi: 10.1016/j.biochi.2010.01.005. Epub 2010 Jan 18. Biochimie. 2010. PMID: 20083151 Free PMC article. Review.

8

HIV-protease inhibitors suppress skeletal muscle fatty acid oxidation by reducing CD36 and CPT1 fatty acid transporters.

Richmond SR, Carper MJ, Lei X, Zhang S, Yarasheski KE, Ramanadham S. Richmond SR, et al. Among authors: lei x. Biochim Biophys Acta. 2010 May;1801(5):559-66. doi: 10.1016/j.bbalip.2010.01.007. Epub 2010 Feb 1. Biochim Biophys Acta. 2010. PMID: 20117238 Free PMC article.

9

A link between endoplasmic reticulum stress-induced β-cell apoptosis and the group VIA Ca2+-independent phospholipase A2 (iPLA2β).

Lei X, Zhang S, Emani B, Barbour SE, Ramanadham S. Lei X, et al. Diabetes Obes Metab. 2010 Oct;12 Suppl 2(0 2):93-8. doi: 10.1111/j.1463-1326.2010.01270.x. Diabetes Obes Metab. 2010. PMID: 21029305 Free PMC article. Review.

10

Role of calcium-independent phospholipase A(2)β in human pancreatic islet β-cell apoptosis.

Lei X, Zhang S, Bohrer A, Barbour SE, Ramanadham S. Lei X, et al. Am J Physiol Endocrinol Metab. 2012 Dec 1;303(11):E1386-95. doi: 10.1152/ajpendo.00234.2012. Epub 2012 Oct 16. Am J Physiol Endocrinol Metab. 2012. PMID: 23074238 Free PMC article.

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