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A MIF-Derived Cyclopeptide that Inhibits MIF Binding and Atherogenic Signaling via the Chemokine Receptor CXCR2.
Krammer C, Kontos C, Dewor M, Hille K, Dalla Volta B, El Bounkari O, Taş K, Sinitski D, Brandhofer M, Megens RTA, Weber C, Schultz JR, Bernhagen J, Kapurniotu A. Krammer C, et al. Among authors: hille k. Chembiochem. 2021 Mar 16;22(6):1012-1019. doi: 10.1002/cbic.202000574. Epub 2020 Nov 30. Chembiochem. 2021. PMID: 33125165 Free PMC article.
Identification of an Arg-Leu-Arg tripeptide that contributes to the binding interface between the cytokine MIF and the chemokine receptor CXCR4.
Lacy M, Kontos C, Brandhofer M, Hille K, Gröning S, Sinitski D, Bourilhon P, Rosenberg E, Krammer C, Thavayogarajah T, Pantouris G, Bakou M, Weber C, Lolis E, Bernhagen J, Kapurniotu A. Lacy M, et al. Among authors: hille k. Sci Rep. 2018 Mar 26;8(1):5171. doi: 10.1038/s41598-018-23554-5. Sci Rep. 2018. PMID: 29581527 Free PMC article.
Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting.
Kontos C, El Bounkari O, Krammer C, Sinitski D, Hille K, Zan C, Yan G, Wang S, Gao Y, Brandhofer M, Megens RTA, Hoffmann A, Pauli J, Asare Y, Gerra S, Bourilhon P, Leng L, Eckstein HH, Kempf WE, Pelisek J, Gokce O, Maegdefessel L, Bucala R, Dichgans M, Weber C, Kapurniotu A, Bernhagen J. Kontos C, et al. Among authors: hille k. Nat Commun. 2020 Nov 25;11(1):5981. doi: 10.1038/s41467-020-19764-z. Nat Commun. 2020. PMID: 33239628 Free PMC article.
Heterocomplexes between the atypical chemokine MIF and the CXC-motif chemokine CXCL4L1 regulate inflammation and thrombus formation.
Brandhofer M, Hoffmann A, Blanchet X, Siminkovitch E, Rohlfing AK, El Bounkari O, Nestele JA, Bild A, Kontos C, Hille K, Rohde V, Fröhlich A, Golemi J, Gokce O, Krammer C, Scheiermann P, Tsilimparis N, Sachs N, Kempf WE, Maegdefessel L, Otabil MK, Megens RTA, Ippel H, Koenen RR, Luo J, Engelmann B, Mayo KH, Gawaz M, Kapurniotu A, Weber C, von Hundelshausen P, Bernhagen J. Brandhofer M, et al. Among authors: hille k. Cell Mol Life Sci. 2022 Sep 12;79(10):512. doi: 10.1007/s00018-022-04539-0. Cell Mol Life Sci. 2022. PMID: 36094626 Free PMC article.
Designed peptides as nanomolar cross-amyloid inhibitors acting via supramolecular nanofiber co-assembly.
Taş K, Volta BD, Lindner C, El Bounkari O, Hille K, Tian Y, Puig-Bosch X, Ballmann M, Hornung S, Ortner M, Prem S, Meier L, Rammes G, Haslbeck M, Weber C, Megens RTA, Bernhagen J, Kapurniotu A. Taş K, et al. Among authors: hille k. Nat Commun. 2022 Aug 25;13(1):5004. doi: 10.1038/s41467-022-32688-0. Nat Commun. 2022. PMID: 36008417 Free PMC article.
Structural Insight into IAPP-Derived Amyloid Inhibitors and Their Mechanism of Action.
Niu Z, Prade E, Malideli E, Hille K, Jussupow A, Mideksa YG, Yan LM, Qian C, Fleisch M, Messias AC, Sarkar R, Sattler M, Lamb DC, Feige MJ, Camilloni C, Kapurniotu A, Reif B. Niu Z, et al. Among authors: hille k. Angew Chem Int Ed Engl. 2020 Mar 27;59(14):5771-5781. doi: 10.1002/anie.201914559. Epub 2020 Jan 28. Angew Chem Int Ed Engl. 2020. PMID: 31863711 Free PMC article.
102 results