Howell BA - Search Results

1

Application of the DILIsym® Quantitative Systems Toxicology drug-induced liver injury model to evaluate the carcinogenic hazard potential of acetaminophen.

Eichenbaum G, Yang K, Gebremichael Y, Howell BA, Murray FJ, Jacobson-Kram D, Jaeschke H, Kuffner E, Gelotte CK, Lai JCK, Wikoff D, Atillasoy E. Eichenbaum G, et al. Among authors: howell ba. Regul Toxicol Pharmacol. 2020 Dec;118:104788. doi: 10.1016/j.yrtph.2020.104788. Epub 2020 Oct 22. Regul Toxicol Pharmacol. 2020. PMID: 33153971 Free article.

2

An analysis of N-acetylcysteine treatment for acetaminophen overdose using a systems model of drug-induced liver injury.

Woodhead JL, Howell BA, Yang Y, Harrill AH, Clewell HJ 3rd, Andersen ME, Siler SQ, Watkins PB. Woodhead JL, et al. Among authors: howell ba. J Pharmacol Exp Ther. 2012 Aug;342(2):529-40. doi: 10.1124/jpet.112.192930. Epub 2012 May 16. J Pharmacol Exp Ther. 2012. PMID: 22593093

3

Use of a systems model of drug-induced liver injury (DILIsym(®)) to elucidate the mechanistic differences between acetaminophen and its less-toxic isomer, AMAP, in mice.

Howell BA, Siler SQ, Watkins PB. Howell BA, et al. Toxicol Lett. 2014 Apr 21;226(2):163-72. doi: 10.1016/j.toxlet.2014.02.007. Epub 2014 Feb 18. Toxicol Lett. 2014. PMID: 24560604 Free article.

4

Systems pharmacology modeling predicts delayed presentation and species differences in bile acid-mediated troglitazone hepatotoxicity.

Yang K, Woodhead JL, Watkins PB, Howell BA, Brouwer KL. Yang K, et al. Among authors: howell ba. Clin Pharmacol Ther. 2014 Nov;96(5):589-98. doi: 10.1038/clpt.2014.158. Epub 2014 Jul 28. Clin Pharmacol Ther. 2014. PMID: 25068506 Free PMC article.

5

Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury.

Woodhead JL, Yang K, Siler SQ, Watkins PB, Brouwer KL, Barton HA, Howell BA. Woodhead JL, et al. Among authors: howell ba. Front Pharmacol. 2014 Nov 7;5:240. doi: 10.3389/fphar.2014.00240. eCollection 2014. Front Pharmacol. 2014. PMID: 25426072 Free PMC article.

6

Elucidating Differences in the Hepatotoxic Potential of Tolcapone and Entacapone With DILIsym(®), a Mechanistic Model of Drug-Induced Liver Injury.

Longo DM, Yang Y, Watkins PB, Howell BA, Siler SQ. Longo DM, et al. Among authors: howell ba. CPT Pharmacometrics Syst Pharmacol. 2016 Jan;5(1):31-9. doi: 10.1002/psp4.12053. Epub 2016 Jan 13. CPT Pharmacometrics Syst Pharmacol. 2016. PMID: 26844013 Free PMC article.

7

Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury.

Yang K, Guo C, Woodhead JL, St Claire RL 3rd, Watkins PB, Siler SQ, Howell BA, Brouwer KLR. Yang K, et al. Among authors: howell ba. J Pharm Sci. 2016 Feb;105(2):443-459. doi: 10.1016/j.xphs.2015.11.008. J Pharm Sci. 2016. PMID: 26869411 Free PMC article. Review.

8

Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors.

Woodhead JL, Brock WJ, Roth SE, Shoaf SE, Brouwer KL, Church R, Grammatopoulos TN, Stiles L, Siler SQ, Howell BA, Mosedale M, Watkins PB, Shoda LK. Woodhead JL, et al. Among authors: howell ba. Toxicol Sci. 2017 Jan;155(1):61-74. doi: 10.1093/toxsci/kfw193. Epub 2016 Sep 21. Toxicol Sci. 2017. PMID: 27655350 Free PMC article.

9

Systems pharmacology modeling of drug-induced hyperbilirubinemia: Differentiating hepatotoxicity and inhibition of enzymes/transporters.

Yang K, Battista C, Woodhead JL, Stahl SH, Mettetal JT, Watkins PB, Siler SQ, Howell BA. Yang K, et al. Among authors: howell ba. Clin Pharmacol Ther. 2017 Apr;101(4):501-509. doi: 10.1002/cpt.619. Epub 2017 Feb 17. Clin Pharmacol Ther. 2017. PMID: 28074467 Free PMC article.

10

Using Quantitative Systems Toxicology to Investigate Observed Species Differences in CKA-Mediated Hepatotoxicity.

Battista C, Yang K, Stahl SH, Mettetal JT, Watkins PB, Siler SQ, Howell BA. Battista C, et al. Among authors: howell ba. Toxicol Sci. 2018 Nov 1;166(1):123-130. doi: 10.1093/toxsci/kfy191. Toxicol Sci. 2018. PMID: 30060248 Free PMC article. Clinical Trial.

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