Jaeschke H - Search Results

1

Application of the DILIsym® Quantitative Systems Toxicology drug-induced liver injury model to evaluate the carcinogenic hazard potential of acetaminophen.

Eichenbaum G, Yang K, Gebremichael Y, Howell BA, Murray FJ, Jacobson-Kram D, Jaeschke H, Kuffner E, Gelotte CK, Lai JCK, Wikoff D, Atillasoy E. Eichenbaum G, et al. Among authors: jaeschke h. Regul Toxicol Pharmacol. 2020 Dec;118:104788. doi: 10.1016/j.yrtph.2020.104788. Epub 2020 Oct 22. Regul Toxicol Pharmacol. 2020. PMID: 33153971 Free article.

2

Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine.

Saito C, Zwingmann C, Jaeschke H. Saito C, et al. Among authors: jaeschke h. Hepatology. 2010 Jan;51(1):246-54. doi: 10.1002/hep.23267. Hepatology. 2010. PMID: 19821517 Free PMC article.

3

c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity.

Saito C, Lemasters JJ, Jaeschke H. Saito C, et al. Among authors: jaeschke h. Toxicol Appl Pharmacol. 2010 Jul;246(1-2):8-17. doi: 10.1016/j.taap.2010.04.015. Epub 2010 Apr 25. Toxicol Appl Pharmacol. 2010. PMID: 20423716 Free PMC article.

4

Acetaminophen-induced hepatic neutrophil accumulation and inflammatory liver injury in CD18-deficient mice.

Williams CD, Bajt ML, Farhood A, Jaeschke H. Williams CD, et al. Among authors: jaeschke h. Liver Int. 2010 Oct;30(9):1280-92. doi: 10.1111/j.1478-3231.2010.02284.x. Liver Int. 2010. PMID: 20500806 Free PMC article.

5

The oxygen tension modulates acetaminophen-induced mitochondrial oxidant stress and cell injury in cultured hepatocytes.

Yan HM, Ramachandran A, Bajt ML, Lemasters JJ, Jaeschke H. Yan HM, et al. Among authors: jaeschke h. Toxicol Sci. 2010 Oct;117(2):515-23. doi: 10.1093/toxsci/kfq208. Epub 2010 Jul 8. Toxicol Sci. 2010. PMID: 20616211 Free PMC article.

6

Role of caspase-1 and interleukin-1beta in acetaminophen-induced hepatic inflammation and liver injury.

Williams CD, Farhood A, Jaeschke H. Williams CD, et al. Among authors: jaeschke h. Toxicol Appl Pharmacol. 2010 Sep 15;247(3):169-78. doi: 10.1016/j.taap.2010.07.004. Epub 2010 Jul 15. Toxicol Appl Pharmacol. 2010. PMID: 20637792 Free PMC article.

7

Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury.

Ramachandran A, Lebofsky M, Baines CP, Lemasters JJ, Jaeschke H. Ramachandran A, et al. Among authors: jaeschke h. Free Radic Res. 2011 Feb;45(2):156-64. doi: 10.3109/10715762.2010.520319. Epub 2010 Oct 13. Free Radic Res. 2011. PMID: 20942566 Free PMC article.

8

The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity.

Ramachandran A, Lebofsky M, Weinman SA, Jaeschke H. Ramachandran A, et al. Among authors: jaeschke h. Toxicol Appl Pharmacol. 2011 Mar 15;251(3):226-33. doi: 10.1016/j.taap.2011.01.004. Epub 2011 Jan 15. Toxicol Appl Pharmacol. 2011. PMID: 21241727 Free PMC article.

9

HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity.

McGill MR, Yan HM, Ramachandran A, Murray GJ, Rollins DE, Jaeschke H. McGill MR, et al. Among authors: jaeschke h. Hepatology. 2011 Mar;53(3):974-82. doi: 10.1002/hep.24132. Epub 2011 Feb 11. Hepatology. 2011. PMID: 21319200 Free PMC article.

10

Role of the Nalp3 inflammasome in acetaminophen-induced sterile inflammation and liver injury.

Williams CD, Antoine DJ, Shaw PJ, Benson C, Farhood A, Williams DP, Kanneganti TD, Park BK, Jaeschke H. Williams CD, et al. Among authors: jaeschke h. Toxicol Appl Pharmacol. 2011 May 1;252(3):289-97. doi: 10.1016/j.taap.2011.03.001. Epub 2011 Mar 21. Toxicol Appl Pharmacol. 2011. PMID: 21396389 Free PMC article.

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