Bunch L - Search Results

1

From Methaqualone and Beyond: Structure-Activity Relationship of 6-, 7-, and 8-Substituted 2,3-Diphenyl-quinazolin-4(3H)-ones and in Silico Prediction of Putative Binding Modes of Quinazolin-4(3H)-ones as Positive Allosteric Modulators of GABA_A Receptors.

Wang PF, Jensen AA, Bunch L. Wang PF, et al. Among authors: bunch l. ACS Chem Neurosci. 2020 Dec 16;11(24):4362-4375. doi: 10.1021/acschemneuro.0c00600. Epub 2020 Nov 10. ACS Chem Neurosci. 2020. PMID: 33170625

2

Azetidinic amino acids: stereocontrolled synthesis and pharmacological characterization as ligands for glutamate receptors and transporters.

Bräuner-Osborne H, Bunch L, Chopin N, Couty F, Evano G, Jensen AA, Kusk M, Nielsen B, Rabasso N. Bräuner-Osborne H, et al. Among authors: bunch l. Org Biomol Chem. 2005 Nov 7;3(21):3926-36. doi: 10.1039/b509514j. Epub 2005 Sep 29. Org Biomol Chem. 2005. PMID: 16240010

3

Chemoenzymatic synthesis of a series of 4-substituted glutamate analogues and pharmacological characterization at human glutamate transporters subtypes 1-3.

Alaux S, Kusk M, Sagot E, Bolte J, Jensen AA, Bräuner-Osborne H, Gefflaut T, Bunch L. Alaux S, et al. Among authors: bunch l. J Med Chem. 2005 Dec 15;48(25):7980-92. doi: 10.1021/jm050597z. J Med Chem. 2005. PMID: 16335922

4

Rational design and enantioselective synthesis of (1R,4S,5R,6S)-3-azabicyclo[3.3.0]octane-4,6-dicarboxylic acid - a novel inhibitor at human glutamate transporter subtypes 1, 2, and 3.

Bunch L, Nielsen B, Jensen AA, Bräuner-Osborne H. Bunch L, et al. J Med Chem. 2006 Jan 12;49(1):172-8. doi: 10.1021/jm0508336. J Med Chem. 2006. PMID: 16392801

5

Stereoselective chemoenzymatic synthesis of the four stereoisomers of l-2-(2-carboxycyclobutyl)glycine and pharmacological characterization at human excitatory amino acid transporter subtypes 1, 2, and 3.

Faure S, Jensen AA, Maurat V, Gu X, Sagot E, Aitken DJ, Bolte J, Gefflaut T, Bunch L. Faure S, et al. Among authors: bunch l. J Med Chem. 2006 Nov 2;49(22):6532-8. doi: 10.1021/jm060822s. J Med Chem. 2006. PMID: 17064071

6

Chemo-enzymatic synthesis of (2S,4R)-2-amino-4-(3-(2,2-diphenylethylamino)-3-oxopropyl)pentanedioic acid: a novel selective inhibitor of human excitatory amino acid transporter subtype 2.

Sagot E, Jensen AA, Pickering DS, Pu X, Umberti M, Stensbøl TB, Nielsen B, Assaf Z, Aboab B, Bolte J, Gefflaut T, Bunch L. Sagot E, et al. Among authors: bunch l. J Med Chem. 2008 Jul 24;51(14):4085-92. doi: 10.1021/jm800091e. Epub 2008 Jun 25. J Med Chem. 2008. PMID: 18578477 Free article.

7

Discovery of the first selective inhibitor of excitatory amino acid transporter subtype 1.

Jensen AA, Erichsen MN, Nielsen CW, Stensbøl TB, Kehler J, Bunch L. Jensen AA, et al. Among authors: bunch l. J Med Chem. 2009 Feb 26;52(4):912-5. doi: 10.1021/jm8013458. J Med Chem. 2009. PMID: 19161278

8

Excitatory amino acid transporters as potential drug targets.

Bunch L, Erichsen MN, Jensen AA. Bunch L, et al. Expert Opin Ther Targets. 2009 Jun;13(6):719-31. doi: 10.1517/14728220902926127. Expert Opin Ther Targets. 2009. PMID: 19456273 Review.

9

4,4-Dimethyl- and diastereomeric 4-hydroxy-4-methyl- (2S)-glutamate analogues display distinct pharmacological profiles at ionotropic glutamate receptors and excitatory amino acid transporters.

Bunch L, Pickering DS, Gefflaut T, Vinatier V, Helaine V, Amir A, Nielsen B, Jensen AA. Bunch L, et al. ChemMedChem. 2009 Nov;4(11):1925-9. doi: 10.1002/cmdc.200900258. ChemMedChem. 2009. PMID: 19731281

10

Structure-activity relationship study of first selective inhibitor of excitatory amino acid transporter subtype 1: 2-Amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101).

Erichsen MN, Huynh TH, Abrahamsen B, Bastlund JF, Bundgaard C, Monrad O, Bekker-Jensen A, Nielsen CW, Frydenvang K, Jensen AA, Bunch L. Erichsen MN, et al. Among authors: bunch l. J Med Chem. 2010 Oct 14;53(19):7180-91. doi: 10.1021/jm1009154. J Med Chem. 2010. PMID: 20857912

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