Yang S - Search Results

1

Discovery of 12O-A Novel Oral Multi-Kinase Inhibitor for the Treatment of Solid Tumor.

Fan Y, Huang Z, Wang X, Ma Y, Li Y, Yang S, Shi Y. Fan Y, et al. Among authors: yang s. Molecules. 2020 Nov 9;25(21):5199. doi: 10.3390/molecules25215199. Molecules. 2020. PMID: 33182255 Free PMC article.

2

Pharmacophore modeling and virtual screening for the discovery of new transforming growth factor-beta type I receptor (ALK5) inhibitors.

Ren JX, Li LL, Zou J, Yang L, Yang JL, Yang SY. Ren JX, et al. Eur J Med Chem. 2009 Nov;44(11):4259-65. doi: 10.1016/j.ejmech.2009.07.008. Epub 2009 Jul 16. Eur J Med Chem. 2009. PMID: 19640613

3

Synthesis, structure-activity relationships and preliminary antitumor evaluation of benzothiazole-2-thiol derivatives as novel apoptosis inducers.

Wang Z, Shi XH, Wang J, Zhou T, Xu YZ, Huang TT, Li YF, Zhao YL, Yang L, Yang SY, Yu LT, Wei YQ. Wang Z, et al. Bioorg Med Chem Lett. 2011 Feb 15;21(4):1097-101. doi: 10.1016/j.bmcl.2010.12.124. Epub 2010 Dec 31. Bioorg Med Chem Lett. 2011. PMID: 21262571

4

SKLB1002, a novel potent inhibitor of VEGF receptor 2 signaling, inhibits angiogenesis and tumor growth in vivo.

Zhang S, Cao Z, Tian H, Shen G, Ma Y, Xie H, Liu Y, Zhao C, Deng S, Yang Y, Zheng R, Li W, Zhang N, Liu S, Wang W, Dai L, Shi S, Cheng L, Pan Y, Feng S, Zhao X, Deng H, Yang S, Wei Y. Zhang S, et al. Among authors: yang s, yang y. Clin Cancer Res. 2011 Jul 1;17(13):4439-50. doi: 10.1158/1078-0432.CCR-10-3109. Epub 2011 May 27. Clin Cancer Res. 2011. PMID: 21622720

5

SKLB610: a novel potential inhibitor of vascular endothelial growth factor receptor tyrosine kinases inhibits angiogenesis and tumor growth in vivo.

Cao ZX, Zheng RL, Lin HJ, Luo SD, Zhou Y, Xu YZ, Zeng XX, Wang Z, Zhou LN, Mao YQ, Yang L, Wei YQ, Yu LT, Yang SY, Zhao YL. Cao ZX, et al. Cell Physiol Biochem. 2011;27(5):565-74. doi: 10.1159/000329978. Epub 2011 Jun 15. Cell Physiol Biochem. 2011. PMID: 21691074

6

Discovery of novel fatty acid synthase (FAS) inhibitors based on the structure of ketoaceyl synthase (KS) domain.

Zeng XF, Li WW, Fan HJ, Wang XY, Ji P, Wang ZR, Ma S, Li LL, Ma XF, Yang SY. Zeng XF, et al. Among authors: yang sy. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4742-4. doi: 10.1016/j.bmcl.2011.06.075. Epub 2011 Jun 23. Bioorg Med Chem Lett. 2011. PMID: 21752639

7

Novel pyrazolo[3,4-d]pyrimidine derivatives as potential antitumor agents: exploratory synthesis, preliminary structure-activity relationships, and in vitro biological evaluation.

He HY, Zhao JN, Jia R, Zhao YL, Yang SY, Yu LT, Yang L. He HY, et al. Molecules. 2011 Dec 20;16(12):10685-94. doi: 10.3390/molecules161210685. Molecules. 2011. PMID: 22186955 Free PMC article.

8

SKLB1206, a novel orally available multikinase inhibitor targeting EGFR activating and T790M mutants, ErbB2, ErbB4, and VEGFR2, displays potent antitumor activity both in vitro and in vivo.

Pan Y, Xu Y, Feng S, Luo S, Zheng R, Yang J, Wang L, Zhong L, Yang HY, Wang BL, Yu Y, Liu J, Cao Z, Wang X, Ji P, Wang Z, Chen X, Zhang S, Wei YQ, Yang SY. Pan Y, et al. Among authors: yang sy, yang hy, yang j. Mol Cancer Ther. 2012 Apr;11(4):952-62. doi: 10.1158/1535-7163.MCT-11-0679. Epub 2012 Feb 8. Mol Cancer Ther. 2012. PMID: 22319204

9

Discovery of the novel potent and selective FLT3 inhibitor 1-{5-[7-(3- morpholinopropoxy)quinazolin-4-ylthio]-[1,3,4]thiadiazol-2-yl}-3-p-tolylurea and its anti-acute myeloid leukemia (AML) activities in vitro and in vivo.

Li WW, Wang XY, Zheng RL, Yan HX, Cao ZX, Zhong L, Wang ZR, Ji P, Yang LL, Wang LJ, Xu Y, Liu JJ, Yang J, Zhang CH, Ma S, Feng S, Sun QZ, Wei YQ, Yang SY. Li WW, et al. Among authors: yang sy, yang ll, yang j. J Med Chem. 2012 Apr 26;55(8):3852-66. doi: 10.1021/jm300042x. Epub 2012 Apr 6. J Med Chem. 2012. PMID: 22452518

10

Identification of novel anaplastic lymphoma kinase (ALK) inhibitors using a common feature pharmacophore model derived from known ligands crystallized with ALK.

Xie HZ, Lan H, Pan YL, Zou J, Wang ZR, Li LL, Huang Q, Zhang H, Yang SY. Xie HZ, et al. Chem Biol Drug Des. 2013 Feb;81(2):175-84. doi: 10.1111/cbdd.12084. Epub 2012 Nov 27. Chem Biol Drug Des. 2013. PMID: 23107363

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