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Page 1
Treatment with epigenetic agents profoundly inhibits tumor growth in leiomyosarcoma.
De Carvalho Fischer C, Hu Y, Morreale M, Lin WY, Wali A, Thakar M, Karunasena E, Sen R, Cai Y, Murphy L, Zahnow CA, Keer H, Thakar M, Ahuja N. De Carvalho Fischer C, et al. Among authors: thakar m. Oncotarget. 2018 Apr 10;9(27):19379-19395. doi: 10.18632/oncotarget.25056. eCollection 2018 Apr 10. Oncotarget. 2018. PMID: 29721210 Free PMC article.
CoGAPS matrix factorization algorithm identifies transcriptional changes in AP-2alpha target genes in feedback from therapeutic inhibition of the EGFR network.
Fertig EJ, Ozawa H, Thakar M, Howard JD, Kagohara LT, Krigsfeld G, Ranaweera RS, Hughes RM, Perez J, Jones S, Favorov AV, Carey J, Stein-O'Brien G, Gaykalova DA, Ochs MF, Chung CH. Fertig EJ, et al. Among authors: thakar m. Oncotarget. 2016 Nov 8;7(45):73845-73864. doi: 10.18632/oncotarget.12075. Oncotarget. 2016. PMID: 27650546 Free PMC article.
Decreased SMAD4 expression is associated with induction of epithelial-to-mesenchymal transition and cetuximab resistance in head and neck squamous cell carcinoma.
Cheng H, Fertig EJ, Ozawa H, Hatakeyama H, Howard JD, Perez J, Considine M, Thakar M, Ranaweera R, Krigsfeld G, Chung CH. Cheng H, et al. Among authors: thakar m. Cancer Biol Ther. 2015;16(8):1252-8. doi: 10.1080/15384047.2015.1056418. Epub 2015 Jun 5. Cancer Biol Ther. 2015. PMID: 26046389 Free PMC article.
Integrated time course omics analysis distinguishes immediate therapeutic response from acquired resistance.
Stein-O'Brien G, Kagohara LT, Li S, Thakar M, Ranaweera R, Ozawa H, Cheng H, Considine M, Schmitz S, Favorov AV, Danilova LV, Califano JA, Izumchenko E, Gaykalova DA, Chung CH, Fertig EJ. Stein-O'Brien G, et al. Among authors: thakar m. Genome Med. 2018 May 23;10(1):37. doi: 10.1186/s13073-018-0545-2. Genome Med. 2018. PMID: 29792227 Free PMC article.
The active Zot domain (aa 288-293) increases ZO-1 and myosin 1C serine/threonine phosphorylation, alters interaction between ZO-1 and its binding partners, and induces tight junction disassembly through proteinase activated receptor 2 activation.
Goldblum SE, Rai U, Tripathi A, Thakar M, De Leo L, Di Toro N, Not T, Ramachandran R, Puche AC, Hollenberg MD, Fasano A. Goldblum SE, et al. Among authors: thakar m. FASEB J. 2011 Jan;25(1):144-58. doi: 10.1096/fj.10-158972. Epub 2010 Sep 17. FASEB J. 2011. PMID: 20852064 Free PMC article.
257 results