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Characterization of application scenario-dependent pharmacokinetics and pharmacodynamic properties of permethrin and hyperforin in a dynamic skin and liver multi-organ-chip model.
Kühnl J, Tao TP, Brandmair K, Gerlach S, Rings T, Müller-Vieira U, Przibilla J, Genies C, Jaques-Jamin C, Schepky A, Marx U, Hewitt NJ, Maschmeyer I. Kühnl J, et al. Among authors: hewitt nj. Toxicology. 2021 Jan 30;448:152637. doi: 10.1016/j.tox.2020.152637. Epub 2020 Nov 18. Toxicology. 2021. PMID: 33220337
A strategy for systemic toxicity assessment based on non-animal approaches: The Cosmetics Europe Long Range Science Strategy programme.
Desprez B, Dent M, Keller D, Klaric M, Ouédraogo G, Cubberley R, Duplan H, Eilstein J, Ellison C, Grégoire S, Hewitt NJ, Jacques-Jamin C, Lange D, Roe A, Rothe H, Blaauboer BJ, Schepky A, Mahony C. Desprez B, et al. Among authors: hewitt nj. Toxicol In Vitro. 2018 Aug;50:137-146. doi: 10.1016/j.tiv.2018.02.017. Epub 2018 Mar 2. Toxicol In Vitro. 2018. PMID: 29499337 Review.
Comparison of the metabolism of 10 chemicals in human and pig skin explants.
Géniès C, Jamin EL, Debrauwer L, Zalko D, Person EN, Eilstein J, Grégoire S, Schepky A, Lange D, Ellison C, Roe A, Salhi S, Cubberley R, Hewitt NJ, Rothe H, Klaric M, Duplan H, Jacques-Jamin C. Géniès C, et al. Among authors: hewitt nj. J Appl Toxicol. 2019 Feb;39(2):385-397. doi: 10.1002/jat.3730. Epub 2018 Oct 21. J Appl Toxicol. 2019. PMID: 30345528 Free PMC article.
Challenges in working towards an internal threshold of toxicological concern (iTTC) for use in the safety assessment of cosmetics: Discussions from the Cosmetics Europe iTTC Working Group workshop.
Ellison CA, Blackburn KL, Carmichael PL, Clewell HJ 3rd, Cronin MTD, Desprez B, Escher SE, Ferguson SS, Grégoire S, Hewitt NJ, Hollnagel HM, Klaric M, Patel A, Salhi S, Schepky A, Schmitt BG, Wambaugh JF, Worth A. Ellison CA, et al. Among authors: hewitt nj. Regul Toxicol Pharmacol. 2019 Apr;103:63-72. doi: 10.1016/j.yrtph.2019.01.016. Epub 2019 Jan 15. Regul Toxicol Pharmacol. 2019. PMID: 30653989 Free PMC article. Review.
Measurement of the penetration of 56 cosmetic relevant chemicals into and through human skin using a standardized protocol.
Hewitt NJ, Grégoire S, Cubberley R, Duplan H, Eilstein J, Ellison C, Lester C, Fabian E, Fernandez J, Géniès C, Jacques-Jamin C, Klaric M, Rothe H, Sorrell I, Lange D, Schepky A. Hewitt NJ, et al. J Appl Toxicol. 2020 Mar;40(3):403-415. doi: 10.1002/jat.3913. Epub 2019 Dec 22. J Appl Toxicol. 2020. PMID: 31867769 Free PMC article.
Use of human liver and EpiSkin™ S9 subcellular fractions as a screening assays to compare the in vitro hepatic and dermal metabolism of 47 cosmetics-relevant chemicals.
Eilstein J, Grégoire S, Fabre A, Arbey E, Géniès C, Duplan H, Rothe H, Ellison C, Cubberley R, Schepky A, Lange D, Klaric M, Hewitt NJ, Jacques-Jamin C. Eilstein J, et al. Among authors: hewitt nj. J Appl Toxicol. 2020 Mar;40(3):416-433. doi: 10.1002/jat.3914. Epub 2020 Jan 8. J Appl Toxicol. 2020. PMID: 31912921
Partition coefficient and diffusion coefficient determinations of 50 compounds in human intact skin, isolated skin layers and isolated stratum corneum lipids.
Ellison CA, Tankersley KO, Obringer CM, Carr GJ, Manwaring J, Rothe H, Duplan H, Géniès C, Grégoire S, Hewitt NJ, Jamin CJ, Klaric M, Lange D, Rolaki A, Schepky A. Ellison CA, et al. Among authors: hewitt nj. Toxicol In Vitro. 2020 Dec;69:104990. doi: 10.1016/j.tiv.2020.104990. Epub 2020 Sep 1. Toxicol In Vitro. 2020. PMID: 32882340 Free article.
93 results