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Angiopoietin-like protein 4 deficiency augments liver fibrosis in liver diseases such as nonalcoholic steatohepatitis in mice through enhanced free cholesterol accumulation in hepatic stellate cells.
Teratani T, Tomita K, Wada A, Sugihara N, Higashiyama M, Inaba K, Horiuchi K, Hanawa Y, Nishii S, Mizoguchi A, Tanemoto R, Ito S, Okada Y, Kurihara C, Akita Y, Narimatsu K, Watanabe C, Komoto S, Oike Y, Miura S, Hokari R, Kanai T. Teratani T, et al. Among authors: tomita k. Hepatol Res. 2021 May;51(5):580-592. doi: 10.1111/hepr.13603. Epub 2021 Apr 7. Hepatol Res. 2021. PMID: 33247991
A high-cholesterol diet exacerbates liver fibrosis in mice via accumulation of free cholesterol in hepatic stellate cells.
Teratani T, Tomita K, Suzuki T, Oshikawa T, Yokoyama H, Shimamura K, Tominaga S, Hiroi S, Irie R, Okada Y, Kurihara C, Ebinuma H, Saito H, Hokari R, Sugiyama K, Kanai T, Miura S, Hibi T. Teratani T, et al. Among authors: tomita k. Gastroenterology. 2012 Jan;142(1):152-164.e10. doi: 10.1053/j.gastro.2011.09.049. Epub 2011 Oct 10. Gastroenterology. 2012. PMID: 21995947
HIF-1 in T cells ameliorated dextran sodium sulfate-induced murine colitis.
Higashiyama M, Hokari R, Hozumi H, Kurihara C, Ueda T, Watanabe C, Tomita K, Nakamura M, Komoto S, Okada Y, Kawaguchi A, Nagao S, Suematsu M, Goda N, Miura S. Higashiyama M, et al. Among authors: tomita k. J Leukoc Biol. 2012 Jun;91(6):901-9. doi: 10.1189/jlb.1011518. Epub 2012 Mar 27. J Leukoc Biol. 2012. PMID: 22457366 Clinical Trial.
p53/p66Shc-mediated signaling contributes to the progression of non-alcoholic steatohepatitis in humans and mice.
Tomita K, Teratani T, Suzuki T, Oshikawa T, Yokoyama H, Shimamura K, Nishiyama K, Mataki N, Irie R, Minamino T, Okada Y, Kurihara C, Ebinuma H, Saito H, Shimizu I, Yoshida Y, Hokari R, Sugiyama K, Hatsuse K, Yamamoto J, Kanai T, Miura S, Hibi T. Tomita K, et al. J Hepatol. 2012 Oct;57(4):837-43. doi: 10.1016/j.jhep.2012.05.013. Epub 2012 May 26. J Hepatol. 2012. PMID: 22641095
2,424 results