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A human tissue map of 5-hydroxymethylcytosines exhibits tissue specificity through gene and enhancer modulation.
Cui XL, Nie J, Ku J, Dougherty U, West-Szymanski DC, Collin F, Ellison CK, Sieh L, Ning Y, Deng Z, Zhao CWT, Bergamaschi A, Pekow J, Wei J, Beadell AV, Zhang Z, Sharma G, Talwar R, Arensdorf P, Karpus J, Goel A, Bissonnette M, Zhang W, Levy S, He C. Cui XL, et al. Among authors: deng z. Nat Commun. 2020 Dec 2;11(1):6161. doi: 10.1038/s41467-020-20001-w. Nat Commun. 2020. PMID: 33268789 Free PMC article.
miR-4728-3p Functions as a Tumor Suppressor in Ulcerative Colitis-associated Colorectal Neoplasia Through Regulation of Focal Adhesion Signaling.
Pekow J, Hutchison AL, Meckel K, Harrington K, Deng Z, Talasila N, Rubin DT, Hanauer SB, Hurst R, Umanskiy K, Fichera A, Hart J, Dinner AR, Bissonnette M. Pekow J, et al. Among authors: deng z. Inflamm Bowel Dis. 2017 Aug;23(8):1328-1337. doi: 10.1097/MIB.0000000000001104. Inflamm Bowel Dis. 2017. PMID: 28594651 Free PMC article.
miR-193a-3p is a Key Tumor Suppressor in Ulcerative Colitis-Associated Colon Cancer and Promotes Carcinogenesis through Upregulation of IL17RD.
Pekow J, Meckel K, Dougherty U, Huang Y, Chen X, Almoghrabi A, Mustafi R, Ayaloglu-Butun F, Deng Z, Haider HI, Hart J, Rubin DT, Kwon JH, Bissonnette M. Pekow J, et al. Among authors: deng z. Clin Cancer Res. 2017 Sep 1;23(17):5281-5291. doi: 10.1158/1078-0432.CCR-17-0171. Epub 2017 Jun 9. Clin Cancer Res. 2017. PMID: 28600480 Free PMC article.
Upregulation of polycistronic microRNA-143 and microRNA-145 in colonocytes suppresses colitis and inflammation-associated colon cancer.
Dougherty U, Mustafi R, Zhu H, Zhu X, Deb D, Meredith SC, Ayaloglu-Butun F, Fletcher M, Sanchez A, Pekow J, Deng Z, Amini N, Konda VJ, Rao VL, Sakuraba A, Kwesi A, Kupfer SS, Fichera A, Joseph L, Hart J, He F, He TC, West-Szymanski D, Li YC, Bissonnette M. Dougherty U, et al. Among authors: deng z. Epigenetics. 2021 Dec;16(12):1317-1334. doi: 10.1080/15592294.2020.1863117. Epub 2020 Dec 28. Epigenetics. 2021. PMID: 33356812 Free PMC article.
Machine learning identifies cell-free DNA 5-hydroxymethylation biomarkers that detect occult colorectal cancer in PLCO Screening Trial subjects.
West-Szymanski DC, Zhang Z, Cui XL, Kowitwanich K, Gao L, Deng Z, Dougherty U, Williams C, Merkle S, Moore M, He C, Bissonnette M, Zhang W. West-Szymanski DC, et al. Among authors: deng z. bioRxiv [Preprint]. 2024 Feb 26:2024.02.25.581955. doi: 10.1101/2024.02.25.581955. bioRxiv. 2024. PMID: 38464122 Free PMC article. Preprint.
LABS: linear amplification-based bisulfite sequencing for ultrasensitive cancer detection from cell-free DNA.
Cui XL, Nie J, Zhu H, Kowitwanich K, Beadell AV, West-Szymanski DC, Zhang Z, Dougherty U, Kwesi A, Deng Z, Li Y, Meng D, Roggin K, Barry T, Owyang R, Fefferman B, Zeng C, Gao L, Zhao CWT, Malina Y, Wei J, Weigert M, Kang W, Goel A, Chiu BC, Bissonnette M, Zhang W, Chen M, He C. Cui XL, et al. Among authors: deng z. Genome Biol. 2024 Jun 14;25(1):157. doi: 10.1186/s13059-024-03262-2. Genome Biol. 2024. PMID: 38877540 Free PMC article.
5-Hydroxymethylated Biomarkers in Cell-Free DNA Predict Occult Colorectal Cancer up to 36 Months Before Diagnosis in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.
West-Szymanski DC, Zhang Z, Cui XL, Kowitwanich K, Gao L, Deng Z, Dougherty U, Williams C, Merkle S, He C, Zhang W, Bissonnette M. West-Szymanski DC, et al. Among authors: deng z. JCO Precis Oncol. 2024 Oct;8:e2400277. doi: 10.1200/PO.24.00277. Epub 2024 Oct 11. JCO Precis Oncol. 2024. PMID: 39393034
8,749 results