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Application of the PET ligand [11C]ORM-13070 to examine receptor occupancy by the α2C-adrenoceptor antagonist ORM-12741: translational validation of target engagement in rat and human brain.
Shahid M, Rinne JO, Scheinin M, Virta J, Marjamäki P, Solin O, Arponen E, Sallinen J, Kuokkanen K, Rouru J. Shahid M, et al. Among authors: scheinin m. EJNMMI Res. 2020 Dec 9;10(1):152. doi: 10.1186/s13550-020-00741-y. EJNMMI Res. 2020. PMID: 33296042 Free PMC article.
Genetic alteration of alpha 2C-adrenoceptor expression in mice: influence on locomotor, hypothermic, and neurochemical effects of dexmedetomidine, a subtype-nonselective alpha 2-adrenoceptor agonist.
Sallinen J, Link RE, Haapalinna A, Viitamaa T, Kulatunga M, Sjöholm B, Macdonald E, Pelto-Huikko M, Leino T, Barsh GS, Kobilka BK, Scheinin M. Sallinen J, et al. Among authors: scheinin m. Mol Pharmacol. 1997 Jan;51(1):36-46. doi: 10.1124/mol.51.1.36. Mol Pharmacol. 1997. PMID: 9016344
Pharmacokinetics and safety of deramciclane during multiple oral dosing.
Kanerva H, Kilkku O, Helminen A, Rouru J, Scheinin M, Huupponen R, Klebovich I, Drabant S, Urtti A. Kanerva H, et al. Among authors: scheinin m. Int J Clin Pharmacol Ther. 1999 Dec;37(12):589-97. Int J Clin Pharmacol Ther. 1999. PMID: 10599951 Clinical Trial.
390 results