Lein PJ - Search Results

1

A non-hallucinogenic psychedelic analogue with therapeutic potential.

Cameron LP, Tombari RJ, Lu J, Pell AJ, Hurley ZQ, Ehinger Y, Vargas MV, McCarroll MN, Taylor JC, Myers-Turnbull D, Liu T, Yaghoobi B, Laskowski LJ, Anderson EI, Zhang G, Viswanathan J, Brown BM, Tjia M, Dunlap LE, Rabow ZT, Fiehn O, Wulff H, McCorvy JD, Lein PJ, Kokel D, Ron D, Peters J, Zuo Y, Olson DE. Cameron LP, et al. Among authors: lein pj. Nature. 2021 Jan;589(7842):474-479. doi: 10.1038/s41586-020-3008-z. Epub 2020 Dec 9. Nature. 2021. PMID: 33299186 Free PMC article.

2

Rapid throughput analysis demonstrates that chemicals with distinct seizurogenic mechanisms differentially alter Ca2+ dynamics in networks formed by hippocampal neurons in culture.

Cao Z, Zou X, Cui Y, Hulsizer S, Lein PJ, Wulff H, Pessah IN. Cao Z, et al. Among authors: lein pj. Mol Pharmacol. 2015 Apr;87(4):595-605. doi: 10.1124/mol.114.096701. Epub 2015 Jan 12. Mol Pharmacol. 2015. PMID: 25583085 Free PMC article.

3

Chasing the Elusive Benzofuran Impurity of the THR Antagonist NH-3: Synthesis, Isotope Labeling, and Biological Activity.

Singh L, Pressly B, Mengeling BJ, Fettinger JC, Furlow JD, Lein PJ, Wulff H, Singh V. Singh L, et al. Among authors: lein pj. J Org Chem. 2016 Mar 4;81(5):1870-6. doi: 10.1021/acs.joc.5b02665. Epub 2016 Feb 18. J Org Chem. 2016. PMID: 26849160

4

Models to identify treatments for the acute and persistent effects of seizure-inducing chemical threat agents.

Pessah IN, Rogawski MA, Tancredi DJ, Wulff H, Zolkowska D, Bruun DA, Hammock BD, Lein PJ. Pessah IN, et al. Among authors: lein pj. Ann N Y Acad Sci. 2016 Aug;1378(1):124-136. doi: 10.1111/nyas.13137. Epub 2016 Jul 28. Ann N Y Acad Sci. 2016. PMID: 27467073 Free PMC article. Review.

5

From the Cover: BDE-47 and BDE-49 Inhibit Axonal Growth in Primary Rat Hippocampal Neuron-Glia Co-Cultures via Ryanodine Receptor-Dependent Mechanisms.

Chen H, Streifel KM, Singh V, Yang D, Mangini L, Wulff H, Lein PJ. Chen H, et al. Among authors: lein pj. Toxicol Sci. 2017 Apr 1;156(2):375-386. doi: 10.1093/toxsci/kfw259. Toxicol Sci. 2017. PMID: 28003438 Free PMC article.

6

A multi-tiered, in vivo, quantitative assay suite for environmental disruptors of thyroid hormone signaling.

Mengeling BJ, Wei Y, Dobrawa LN, Streekstra M, Louisse J, Singh V, Singh L, Lein PJ, Wulff H, Murk AJ, Furlow JD. Mengeling BJ, et al. Among authors: lein pj. Aquat Toxicol. 2017 Sep;190:1-10. doi: 10.1016/j.aquatox.2017.06.019. Epub 2017 Jun 21. Aquat Toxicol. 2017. PMID: 28662416 Free PMC article.

7

Opportunities and challenges for using the zebrafish to study neuronal connectivity as an endpoint of developmental neurotoxicity.

Miller GW, Chandrasekaran V, Yaghoobi B, Lein PJ. Miller GW, et al. Among authors: lein pj. Neurotoxicology. 2018 Jul;67:102-111. doi: 10.1016/j.neuro.2018.04.016. Epub 2018 Apr 25. Neurotoxicology. 2018. PMID: 29704525 Free PMC article. Review.

8

Teratological and Behavioral Screening of the National Toxicology Program 91-Compound Library in Zebrafish (Danio rerio).

Dach K, Yaghoobi B, Schmuck MR, Carty DR, Morales KM, Lein PJ. Dach K, et al. Among authors: lein pj. Toxicol Sci. 2019 Jan 1;167(1):77-91. doi: 10.1093/toxsci/kfy266. Toxicol Sci. 2019. PMID: 30364989 Free PMC article.

9

Effects of thyroid hormone disruption on the ontogenetic expression of thyroid hormone signaling genes in developing zebrafish (Danio rerio).

Walter KM, Miller GW, Chen X, Yaghoobi B, Puschner B, Lein PJ. Walter KM, et al. Among authors: lein pj. Gen Comp Endocrinol. 2019 Feb 1;272:20-32. doi: 10.1016/j.ygcen.2018.11.007. Epub 2018 Nov 15. Gen Comp Endocrinol. 2019. PMID: 30448381 Free PMC article.

10

Identification of Psychoplastogenic N,N-Dimethylaminoisotryptamine (isoDMT) Analogues through Structure-Activity Relationship Studies.

Dunlap LE, Azinfar A, Ly C, Cameron LP, Viswanathan J, Tombari RJ, Myers-Turnbull D, Taylor JC, Grodzki AC, Lein PJ, Kokel D, Olson DE. Dunlap LE, et al. Among authors: lein pj. J Med Chem. 2020 Feb 13;63(3):1142-1155. doi: 10.1021/acs.jmedchem.9b01404. Epub 2020 Jan 24. J Med Chem. 2020. PMID: 31977208 Free PMC article.

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