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ATP13A3 is a major component of the enigmatic mammalian polyamine transport system.
Hamouda NN, Van den Haute C, Vanhoutte R, Sannerud R, Azfar M, Mayer R, Cortés Calabuig Á, Swinnen JV, Agostinis P, Baekelandt V, Annaert W, Impens F, Verhelst SHL, Eggermont J, Martin S, Vangheluwe P. Hamouda NN, et al. Among authors: eggermont j. J Biol Chem. 2021 Jan-Jun;296:100182. doi: 10.1074/jbc.RA120.013908. Epub 2020 Dec 17. J Biol Chem. 2021. PMID: 33310703 Free PMC article.
Thapsigargin affinity purification of intracellular P(2A)-type Ca(2+) ATPases.
Vandecaetsbeek I, Christensen SB, Liu H, Van Veldhoven PP, Waelkens E, Eggermont J, Raeymaekers L, Møller JV, Nissen P, Wuytack F, Vangheluwe P. Vandecaetsbeek I, et al. Among authors: eggermont j. Biochim Biophys Acta. 2011 May;1813(5):1118-27. doi: 10.1016/j.bbamcr.2010.12.020. Epub 2011 Jan 4. Biochim Biophys Acta. 2011. PMID: 21215281 Free article.
A lipid switch unlocks Parkinson's disease-associated ATP13A2.
Holemans T, Sørensen DM, van Veen S, Martin S, Hermans D, Kemmer GC, Van den Haute C, Baekelandt V, Günther Pomorski T, Agostinis P, Wuytack F, Palmgren M, Eggermont J, Vangheluwe P. Holemans T, et al. Among authors: eggermont j. Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):9040-5. doi: 10.1073/pnas.1508220112. Epub 2015 Jul 1. Proc Natl Acad Sci U S A. 2015. PMID: 26134396 Free PMC article.
Structure/activity relationship of thapsigargin inhibition on the purified Golgi/secretory pathway Ca2+/Mn2+-transport ATPase (SPCA1a).
Chen J, De Raeymaecker J, Hovgaard JB, Smaardijk S, Vandecaetsbeek I, Wuytack F, Møller JV, Eggermont J, De Maeyer M, Christensen SB, Vangheluwe P. Chen J, et al. Among authors: eggermont j. J Biol Chem. 2017 Apr 28;292(17):6938-6951. doi: 10.1074/jbc.M117.778431. Epub 2017 Mar 6. J Biol Chem. 2017. PMID: 28264934 Free PMC article.
Parkinson disease related ATP13A2 evolved early in animal evolution.
Sørensen DM, Holemans T, van Veen S, Martin S, Arslan T, Haagendahl IW, Holen HW, Hamouda NN, Eggermont J, Palmgren M, Vangheluwe P. Sørensen DM, et al. Among authors: eggermont j. PLoS One. 2018 Mar 5;13(3):e0193228. doi: 10.1371/journal.pone.0193228. eCollection 2018. PLoS One. 2018. PMID: 29505581 Free PMC article.
ATP13A2 deficiency disrupts lysosomal polyamine export.
van Veen S, Martin S, Van den Haute C, Benoy V, Lyons J, Vanhoutte R, Kahler JP, Decuypere JP, Gelders G, Lambie E, Zielich J, Swinnen JV, Annaert W, Agostinis P, Ghesquière B, Verhelst S, Baekelandt V, Eggermont J, Vangheluwe P. van Veen S, et al. Among authors: eggermont j. Nature. 2020 Feb;578(7795):419-424. doi: 10.1038/s41586-020-1968-7. Epub 2020 Jan 29. Nature. 2020. PMID: 31996848
372 results