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First-in-man study to investigate safety, pharmacokinetics and exploratory pharmacodynamics of HTL0018318, a novel M1 -receptor partial agonist for the treatment of dementias.
Bakker C, Tasker T, Liptrot J, Hart EP, Klaassen ES, Prins S, van der Doef TF, Brown GA, Brown A, Congreve M, Weir M, Marshall FH, Cross DM, Groeneveld GJ, Nathan PJ. Bakker C, et al. Among authors: groeneveld gj. Br J Clin Pharmacol. 2021 Jul;87(7):2945-2955. doi: 10.1111/bcp.14710. Epub 2021 Feb 5. Br J Clin Pharmacol. 2021. PMID: 33351971 Free PMC article. Clinical Trial.
Pharmacokinetics and pharmacodynamics of multiple doses of BG00010, a neurotrophic factor with anti-hyperalgesic effects, in patients with sciatica.
Okkerse P, Hay JL, Versage E, Tang Y, Galluppi G, Ravina B, Verma A, Williams L, Aycardi E, Groeneveld GJ. Okkerse P, et al. Among authors: groeneveld gj. Br J Clin Pharmacol. 2016 Jul;82(1):108-17. doi: 10.1111/bcp.12941. Epub 2016 May 13. Br J Clin Pharmacol. 2016. PMID: 27016000 Free PMC article. Clinical Trial.
Pharmacokinetics and pharmacodynamics of oral mecamylamine - development of a nicotinic acetylcholine receptor antagonist cognitive challenge test using modelling and simulation.
Alvarez-Jimenez R, Baakman AC, Stevens J, Goulooze SC, Hart EP, Rissmann R, van Gerven JM, Groeneveld GJ. Alvarez-Jimenez R, et al. Among authors: groeneveld gj. J Psychopharmacol. 2017 Feb;31(2):192-203. doi: 10.1177/0269881116681417. Epub 2016 Dec 9. J Psychopharmacol. 2017. PMID: 27927703
Effects on Spasticity and Neuropathic Pain of an Oral Formulation of Δ9-tetrahydrocannabinol in Patients WithProgressive Multiple Sclerosis.
van Amerongen G, Kanhai K, Baakman AC, Heuberger J, Klaassen E, Beumer TL, Strijers RLM, Killestein J, van Gerven J, Cohen A, Groeneveld GJ. van Amerongen G, et al. Among authors: groeneveld gj. Clin Ther. 2018 Sep;40(9):1467-1482. doi: 10.1016/j.clinthera.2017.01.016. Epub 2017 Feb 9. Clin Ther. 2018. PMID: 28189366 Clinical Trial.
152 results