Parnes JR - Search Results

1

Pharmacokinetic and Pharmacodynamic Modeling of Tezepelumab to Guide Phase 3 Dose Selection for Patients With Severe Asthma.

Ly N, Zheng Y, Griffiths JM, van der Merwe R, Agoram B, Parnes JR, Roskos L. Ly N, et al. Among authors: parnes jr. J Clin Pharmacol. 2021 Jul;61(7):901-912. doi: 10.1002/jcph.1803. Epub 2021 Jan 16. J Clin Pharmacol. 2021. PMID: 33368307 Clinical Trial.

2

Tezepelumab in Adults with Uncontrolled Asthma.

Corren J, Parnes JR, Wang L, Mo M, Roseti SL, Griffiths JM, van der Merwe R. Corren J, et al. Among authors: parnes jr. N Engl J Med. 2017 Sep 7;377(10):936-946. doi: 10.1056/NEJMoa1704064. N Engl J Med. 2017. PMID: 28877011 Free article. Clinical Trial.

3

Tezepelumab, an anti-thymic stromal lymphopoietin monoclonal antibody, in the treatment of moderate to severe atopic dermatitis: A randomized phase 2a clinical trial.

Simpson EL, Parnes JR, She D, Crouch S, Rees W, Mo M, van der Merwe R. Simpson EL, et al. Among authors: parnes jr. J Am Acad Dermatol. 2019 Apr;80(4):1013-1021. doi: 10.1016/j.jaad.2018.11.059. Epub 2018 Dec 12. J Am Acad Dermatol. 2019. PMID: 30550828 Free article. Clinical Trial.

4

Pharmacokinetics, Safety, and Tolerability of Tezepelumab (AMG 157) in Healthy and Atopic Dermatitis Adult Subjects.

Parnes JR, Sullivan JT, Chen L, Dias C. Parnes JR, et al. Clin Pharmacol Ther. 2019 Aug;106(2):441-449. doi: 10.1002/cpt.1401. Epub 2019 Mar 23. Clin Pharmacol Ther. 2019. PMID: 30779339 Free PMC article. Clinical Trial.

5

CASCADE: a phase 2, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the effect of tezepelumab on airway inflammation in patients with uncontrolled asthma.

Emson C, Diver S, Chachi L, Megally A, Small C, Downie J, Parnes JR, Bowen K, Colice G, Brightling CE. Emson C, et al. Among authors: parnes jr. Respir Res. 2020 Oct 13;21(1):265. doi: 10.1186/s12931-020-01513-x. Respir Res. 2020. PMID: 33050900 Free PMC article.

6

Tezepelumab improves patient-reported outcomes in patients with severe, uncontrolled asthma in PATHWAY.

Corren J, Garcia Gil E, Griffiths JM, Parnes JR, van der Merwe R, Sałapa K, O'Quinn S. Corren J, et al. Among authors: parnes jr. Ann Allergy Asthma Immunol. 2021 Feb;126(2):187-193. doi: 10.1016/j.anai.2020.10.008. Epub 2020 Oct 23. Ann Allergy Asthma Immunol. 2021. PMID: 33169672 Free article. Clinical Trial.

7

Tezepelumab Reduces Exacerbations Across All Seasons in Patients with Severe, Uncontrolled Asthma: A Post Hoc Analysis of the PATHWAY Phase 2b Study.

Corren J, Karpefors M, Hellqvist Å, Parnes JR, Colice G. Corren J, et al. Among authors: parnes jr. J Asthma Allergy. 2021 Jan 11;14:1-11. doi: 10.2147/JAA.S286036. eCollection 2021. J Asthma Allergy. 2021. PMID: 33469316 Free PMC article.

8

Efficacy of Tezepelumab in Patients with Severe, Uncontrolled Asthma with and without Nasal Polyposis: A Post Hoc Analysis of the Phase 2b PATHWAY Study.

Emson C, Corren J, Sałapa K, Hellqvist Å, Parnes JR, Colice G. Emson C, et al. Among authors: parnes jr. J Asthma Allergy. 2021 Feb 3;14:91-99. doi: 10.2147/JAA.S288260. eCollection 2021. J Asthma Allergy. 2021. PMID: 33568920 Free PMC article.

9

Effect of tezepelumab on airway inflammatory cells, remodelling, and hyperresponsiveness in patients with moderate-to-severe uncontrolled asthma (CASCADE): a double-blind, randomised, placebo-controlled, phase 2 trial.

Diver S, Khalfaoui L, Emson C, Wenzel SE, Menzies-Gow A, Wechsler ME, Johnston J, Molfino N, Parnes JR, Megally A, Colice G, Brightling CE; CASCADE study investigators. Diver S, et al. Among authors: parnes jr. Lancet Respir Med. 2021 Nov;9(11):1299-1312. doi: 10.1016/S2213-2600(21)00226-5. Epub 2021 Jul 10. Lancet Respir Med. 2021. PMID: 34256031 Clinical Trial.

10

Efficacy of Tezepelumab in Patients with Severe, Uncontrolled Asthma and Perennial Allergy.

Corren J, Ambrose CS, Sałapa K, Roseti SL, Griffiths JM, Parnes JR, Colice G. Corren J, et al. Among authors: parnes jr. J Allergy Clin Immunol Pract. 2021 Dec;9(12):4334-4342.e6. doi: 10.1016/j.jaip.2021.07.045. Epub 2021 Aug 3. J Allergy Clin Immunol Pract. 2021. PMID: 34358701 Free article. Clinical Trial.

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