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Page 1
3,4-Dihydropyrimidin-2(1H)-ones as Antagonists of the Human A2B Adenosine Receptor: Optimization, Structure-Activity Relationship Studies, and Enantiospecific Recognition.
Majellaro M, Jespers W, Crespo A, Núñez MJ, Novio S, Azuaje J, Prieto-Díaz R, Gioé C, Alispahic B, Brea J, Loza MI, Freire-Garabal M, Garcia-Santiago C, Rodríguez-García C, García-Mera X, Caamaño O, Fernandez-Masaguer C, Sardina JF, Stefanachi A, El Maatougui A, Mallo-Abreu A, Åqvist J, Gutiérrez-de-Terán H, Sotelo E. Majellaro M, et al. Among authors: crespo a. J Med Chem. 2021 Jan 14;64(1):458-480. doi: 10.1021/acs.jmedchem.0c01431. Epub 2020 Dec 29. J Med Chem. 2021. PMID: 33372800
Discovery of Potent and Highly Selective A2B Adenosine Receptor Antagonist Chemotypes.
El Maatougui A, Azuaje J, González-Gómez M, Miguez G, Crespo A, Carbajales C, Escalante L, García-Mera X, Gutiérrez-de-Terán H, Sotelo E. El Maatougui A, et al. Among authors: crespo a. J Med Chem. 2016 Mar 10;59(5):1967-83. doi: 10.1021/acs.jmedchem.5b01586. Epub 2016 Feb 9. J Med Chem. 2016. PMID: 26824742
Optimization of 2-Amino-4,6-diarylpyrimidine-5-carbonitriles as Potent and Selective A1 Antagonists.
Val C, Rodríguez-García C, Prieto-Díaz R, Crespo A, Azuaje J, Carbajales C, Majellaro M, Díaz-Holguín A, Brea JM, Loza MI, Gioé-Gallo C, Contino M, Stefanachi A, García-Mera X, Estévez JC, Gutiérrez-de-Terán H, Sotelo E. Val C, et al. Among authors: crespo a. J Med Chem. 2022 Feb 10;65(3):2091-2106. doi: 10.1021/acs.jmedchem.1c01636. Epub 2022 Jan 22. J Med Chem. 2022. PMID: 35068155 Free PMC article.
Convergent assembly of structurally diverse quinazolines.
Crespo A, Coelho A, Diz PM, Fernández F, Novoa de Armas H, Sotelo E. Crespo A, et al. Org Biomol Chem. 2011 Jan 21;9(2):351-7. doi: 10.1039/c0ob00608d. Epub 2010 Nov 3. Org Biomol Chem. 2011. PMID: 21049105
Biomarkers.
Fletcher J, Cano EDPS, Ramírez AVD, Arosemena-Aguero XE, Araujo P, de Roux RW, Balaguer RR, Díaz M, Novarro-Escudero N, Tamayo DAA, Aguilar LP, Villarreal J, Mendoza J, Billingslea V, Juárez J, Courville K, Degracia SZP, Torres H, Benzadon A, Hammerschlag B, Saldaña A, Girón LYQ, Solís DMD, Castillo LMC, Dondis D, Adames AAP, Crespo AEB, Araña SR, Rodriguez C, López N, Oviedo DC, Carreira MB, Rangel G, Villarreal AE, Britton GB. Fletcher J, et al. Among authors: crespo aeb. Alzheimers Dement. 2024 Dec;20 Suppl 2:e086130. doi: 10.1002/alz.086130. Alzheimers Dement. 2024. PMID: 39786218
564 results