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Page 1
3,4-Dihydropyrimidin-2(1H)-ones as Antagonists of the Human A2B Adenosine Receptor: Optimization, Structure-Activity Relationship Studies, and Enantiospecific Recognition.
Majellaro M, Jespers W, Crespo A, Núñez MJ, Novio S, Azuaje J, Prieto-Díaz R, Gioé C, Alispahic B, Brea J, Loza MI, Freire-Garabal M, Garcia-Santiago C, Rodríguez-García C, García-Mera X, Caamaño O, Fernandez-Masaguer C, Sardina JF, Stefanachi A, El Maatougui A, Mallo-Abreu A, Åqvist J, Gutiérrez-de-Terán H, Sotelo E. Majellaro M, et al. Among authors: sotelo e. J Med Chem. 2021 Jan 14;64(1):458-480. doi: 10.1021/acs.jmedchem.0c01431. Epub 2020 Dec 29. J Med Chem. 2021. PMID: 33372800
Synthesis of 1-substituted-6-methyluracils.
Nieto RM, Coelho A, Martínez A, Stefanachi A, Sotelo E, Raviña E. Nieto RM, et al. Among authors: sotelo e. Chem Pharm Bull (Tokyo). 2003 Sep;51(9):1025-8. doi: 10.1248/cpb.51.1025. Chem Pharm Bull (Tokyo). 2003. PMID: 12951442 Free article.
Pyridazines part 41: synthesis, antiplatelet activity and SAR of 2,4,6-substituted 5-(3-oxo-3-phenylprop-1-en-1-yl)- or 5-(3-phenylprop-2-enoyl)pyridazin-3(2H)-ones.
Crespo A, Meyers C, Coelho A, Yáñez M, Fraiz N, Sotelo E, Maes BU, Laguna R, Cano E, Lemière GL, Raviña E. Crespo A, et al. Among authors: sotelo e. Bioorg Med Chem Lett. 2006 Feb 15;16(4):1080-3. doi: 10.1016/j.bmcl.2005.10.073. Epub 2005 Nov 14. Bioorg Med Chem Lett. 2006. PMID: 16290144
2-Substituted 4-, 5-, and 6-[(1E)-3-oxo-3-phenylprop-1-en-1-yl]pyridazin-3(2H)-ones and 2-substituted 4,5-bis[(1E)-3-oxo-3-phenylprop-1-en-1-yl]pyridazin-3(2H)-ones as potent platelet aggregation inhibitors: design, synthesis, and SAR studies.
Meyers C, Yáñez M, Elmaatougi A, Verhelst T, Coelho A, Fraiz N, Lemière GL, García-Mera X, Laguna R, Cano E, Maes BU, Sotelo E. Meyers C, et al. Among authors: sotelo e. Bioorg Med Chem Lett. 2008 Jan 15;18(2):793-7. doi: 10.1016/j.bmcl.2007.11.034. Epub 2007 Nov 17. Bioorg Med Chem Lett. 2008. PMID: 18053717
110 results