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Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes in COVID-19 convalescent plasma.
Voss WN, Hou YJ, Johnson NV, Kim JE, Delidakis G, Horton AP, Bartzoka F, Paresi CJ, Tanno Y, Abbasi SA, Pickens W, George K, Boutz DR, Towers DM, McDaniel JR, Billick D, Goike J, Rowe L, Batra D, Pohl J, Lee J, Gangappa S, Sambhara S, Gadush M, Wang N, Person MD, Iverson BL, Gollihar JD, Dye J, Herbert A, Baric RS, McLellan JS, Georgiou G, Lavinder JJ, Ippolito GC. Voss WN, et al. Among authors: hou yj. bioRxiv [Preprint]. 2020 Dec 21:2020.12.20.423708. doi: 10.1101/2020.12.20.423708. bioRxiv. 2020. Update in: Science. 2021 Jun 4;372(6546):1108-1112. doi: 10.1126/science.abg5268 PMID: 33398269 Free PMC article. Updated. Preprint.
A mouse-adapted SARS-CoV-2 model for the evaluation of COVID-19 medical countermeasures.
Dinnon KH, Leist SR, Schäfer A, Edwards CE, Martinez DR, Montgomery SA, West A, Yount BL, Hou YJ, Adams LE, Gully KL, Brown AJ, Huang E, Bryant MD, Choong IC, Glenn JS, Gralinski LE, Sheahan TP, Baric RS. Dinnon KH, et al. Among authors: hou yj. bioRxiv [Preprint]. 2020 May 7:2020.05.06.081497. doi: 10.1101/2020.05.06.081497. bioRxiv. 2020. Update in: Nature. 2020 Oct;586(7830):560-566. doi: 10.1038/s41586-020-2708-8 PMID: 32511406 Free PMC article. Updated. Preprint.
The RBD Of The Spike Protein Of SARS-Group Coronaviruses Is A Highly Specific Target Of SARS-CoV-2 Antibodies But Not Other Pathogenic Human and Animal Coronavirus Antibodies.
Premkumar L, Segovia-Chumbez B, Jadi R, Martinez DR, Raut R, Markmann A, Cornaby C, Bartelt L, Weiss S, Park Y, Edwards CE, Weimer E, Scherer EM, Roupael N, Edupuganti S, Weiskopf D, Tse LV, Hou YJ, Margolis D, Sette A, Collins MH, Schmitz J, Baric RS, de Silva AM. Premkumar L, et al. Among authors: hou yj. medRxiv [Preprint]. 2020 May 10:2020.05.06.20093377. doi: 10.1101/2020.05.06.20093377. medRxiv. 2020. Update in: Sci Immunol. 2020 Jun 11;5(48):eabc8413. doi: 10.1126/sciimmunol.abc8413 PMID: 32511572 Free PMC article. Updated. Preprint.
Specific viral RNA drives the SARS CoV-2 nucleocapsid to phase separate.
Iserman C, Roden C, Boerneke M, Sealfon R, McLaughlin G, Jungreis I, Park C, Boppana A, Fritch E, Hou YJ, Theesfeld C, Troyanskaya OG, Baric RS, Sheahan TP, Weeks K, Gladfelter AS. Iserman C, et al. Among authors: hou yj. bioRxiv [Preprint]. 2020 Jun 12:2020.06.11.147199. doi: 10.1101/2020.06.11.147199. bioRxiv. 2020. PMID: 32587965 Free PMC article. Preprint.
Cryo-electron Microscopy and Exploratory Antisense Targeting of the 28-kDa Frameshift Stimulation Element from the SARS-CoV-2 RNA Genome.
Zhang K, Zheludev IN, Hagey RJ, Wu MT, Haslecker R, Hou YJ, Kretsch R, Pintilie GD, Rangan R, Kladwang W, Li S, Pham EA, Bernardin-Souibgui C, Baric RS, Sheahan TP, D Souza V, Glenn JS, Chiu W, Das R. Zhang K, et al. Among authors: hou yj. bioRxiv [Preprint]. 2020 Jul 20:2020.07.18.209270. doi: 10.1101/2020.07.18.209270. bioRxiv. 2020. Update in: Nat Struct Mol Biol. 2021 Sep;28(9):747-754. doi: 10.1038/s41594-021-00653-y PMID: 32743589 Free PMC article. Updated. Preprint.
De novo design of ACE2 protein decoys to neutralize SARS-CoV-2.
Linsky TW, Vergara R, Codina N, Nelson JW, Walker MJ, Su W, Hsiang TY, Esser-Nobis K, Yu K, Hou YJ, Priya T, Mitsumoto M, Pong A, Lau UY, Mason ML, Chen J, Chen A, Berrocal T, Peng H, Clairmont NS, Castellanos J, Lin YR, Josephson-Day A, Baric R, Walkey CD, Swanson R, Gale M, Blancas-Mejia LM, Yen HL, Silva DA. Linsky TW, et al. Among authors: hou yj. bioRxiv [Preprint]. 2020 Aug 3:2020.08.03.231340. doi: 10.1101/2020.08.03.231340. bioRxiv. 2020. Update in: Science. 2020 Dec 4;370(6521):1208-1214. doi: 10.1126/science.abe0075 PMID: 32793910 Free PMC article. Updated. Preprint.
SARS-CoV-2 D614G Variant Exhibits Enhanced Replication ex vivo and Earlier Transmission in vivo.
Hou YJ, Chiba S, Halfmann P, Ehre C, Kuroda M, Dinnon KH 3rd, Leist SR, Schäfer A, Nakajima N, Takahashi K, Lee RE, Mascenik TM, Edwards CE, Tse LV, Boucher RC, Randell SH, Suzuki T, Gralinski LE, Kawaoka Y, Baric RS. Hou YJ, et al. bioRxiv [Preprint]. 2020 Sep 29:2020.09.28.317685. doi: 10.1101/2020.09.28.317685. bioRxiv. 2020. Update in: Science. 2020 Dec 18;370(6523):1464-1468. doi: 10.1126/science.abe8499 PMID: 33024969 Free PMC article. Updated. Preprint.
Evaluation of SARS-CoV-2 neutralization assays for antibody monitoring in natural infection and vaccine trials.
Sholukh AM, Fiore-Gartland A, Ford ES, Hou Y, Tse LV, Lempp FA, Kaiser H, Saint Germain R, Bossard E, Kee JJ, Diem K, Stuart AB, Rupert PB, Brock C, Buerger M, Doll MK, Randhawa AK, Stamatatos L, Strong RK, McLaughlin C, Jerome KR, Baric RS, Montefiori D, Corey L. Sholukh AM, et al. medRxiv [Preprint]. 2020 Dec 8:2020.12.07.20245431. doi: 10.1101/2020.12.07.20245431. medRxiv. 2020. PMID: 33330875 Free PMC article. Preprint.
Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody.
Rappazzo CG, Tse LV, Kaku CI, Wrapp D, Sakharkar M, Huang D, Deveau LM, Yockachonis TJ, Herbert AS, Battles MB, O'Brien CM, Brown ME, Geoghegan JC, Belk J, Peng L, Yang L, Hou Y, Scobey TD, Burton DR, Nemazee D, Dye JM, Voss JE, Gunn BM, McLellan JS, Baric RS, Gralinski LE, Walker LM. Rappazzo CG, et al. Science. 2021 Feb 19;371(6531):823-829. doi: 10.1126/science.abf4830. Epub 2021 Jan 25. Science. 2021. PMID: 33495307 Free PMC article.
242 results