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Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape.
Koenig PA, Das H, Liu H, Kümmerer BM, Gohr FN, Jenster LM, Schiffelers LDJ, Tesfamariam YM, Uchima M, Wuerth JD, Gatterdam K, Ruetalo N, Christensen MH, Fandrey CI, Normann S, Tödtmann JMP, Pritzl S, Hanke L, Boos J, Yuan M, Zhu X, Schmid-Burgk JL, Kato H, Schindler M, Wilson IA, Geyer M, Ludwig KU, Hällberg BM, Wu NC, Schmidt FI. Koenig PA, et al. Among authors: fandrey ci. Science. 2021 Feb 12;371(6530):eabe6230. doi: 10.1126/science.abe6230. Epub 2021 Jan 12. Science. 2021. PMID: 33436526 Free PMC article.
NIS-Seq enables cell-type-agnostic optical perturbation screening.
Fandrey CI, Jentzsch M, Konopka P, Hoch A, Blumenstock K, Zackria A, Maasewerd S, Lovotti M, Lapp DJ, Gohr FN, Suwara P, Świeżewski J, Rossnagel L, Gobs F, Cristodaro M, Muhandes L, Behrendt R, Lam MC, Walgenbach KJ, Bald T, Schmidt FI, Latz E, Schmid-Burgk JL. Fandrey CI, et al. Nat Biotechnol. 2024 Dec 19. doi: 10.1038/s41587-024-02516-5. Online ahead of print. Nat Biotechnol. 2024. PMID: 39702735