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Very low mutation burden is a feature of inflamed recurrent glioblastomas responsive to cancer immunotherapy.
Gromeier M, Brown MC, Zhang G, Lin X, Chen Y, Wei Z, Beaubier N, Yan H, He Y, Desjardins A, Herndon JE 2nd, Varn FS, Verhaak RG, Zhao J, Bolognesi DP, Friedman AH, Friedman HS, McSherry F, Muscat AM, Lipp ES, Nair SK, Khasraw M, Peters KB, Randazzo D, Sampson JH, McLendon RE, Bigner DD, Ashley DM. Gromeier M, et al. Among authors: yan h. Nat Commun. 2021 Jan 13;12(1):352. doi: 10.1038/s41467-020-20469-6. Nat Commun. 2021. PMID: 33441554 Free PMC article.
The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma.
Diplas BH, He X, Brosnan-Cashman JA, Liu H, Chen LH, Wang Z, Moure CJ, Killela PJ, Loriaux DB, Lipp ES, Greer PK, Yang R, Rizzo AJ, Rodriguez FJ, Friedman AH, Friedman HS, Wang S, He Y, McLendon RE, Bigner DD, Jiao Y, Waitkus MS, Meeker AK, Yan H. Diplas BH, et al. Among authors: yan h. Nat Commun. 2018 May 25;9(1):2087. doi: 10.1038/s41467-018-04448-6. Nat Commun. 2018. PMID: 29802247 Free PMC article.
The integrated genomic and epigenomic landscape of brainstem glioma.
Chen LH, Pan C, Diplas BH, Xu C, Hansen LJ, Wu Y, Chen X, Geng Y, Sun T, Sun Y, Zhang P, Wu Z, Zhang J, Li D, Zhang Y, Wu W, Wang Y, Li G, Yang J, Wang X, Xu C, Wang S, Waitkus MS, He Y, McLendon RE, Ashley DM, Yan H, Zhang L. Chen LH, et al. Among authors: yan h. Nat Commun. 2020 Jun 17;11(1):3077. doi: 10.1038/s41467-020-16682-y. Nat Commun. 2020. PMID: 32555164 Free PMC article.
Enzyme redesign guided by cancer-derived IDH1 mutations.
Reitman ZJ, Choi BD, Spasojevic I, Bigner DD, Sampson JH, Yan H. Reitman ZJ, et al. Among authors: yan h. Nat Chem Biol. 2012 Nov;8(11):887-9. doi: 10.1038/nchembio.1065. Epub 2012 Sep 23. Nat Chem Biol. 2012. PMID: 23001033 Free PMC article.
The genetic landscape of anaplastic astrocytoma.
Killela PJ, Pirozzi CJ, Reitman ZJ, Jones S, Rasheed BA, Lipp E, Friedman H, Friedman AH, He Y, McLendon RE, Bigner DD, Yan H. Killela PJ, et al. Among authors: yan h. Oncotarget. 2014 Mar 30;5(6):1452-7. doi: 10.18632/oncotarget.1505. Oncotarget. 2014. PMID: 24140581 Free PMC article.
Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas.
Killela PJ, Pirozzi CJ, Healy P, Reitman ZJ, Lipp E, Rasheed BA, Yang R, Diplas BH, Wang Z, Greer PK, Zhu H, Wang CY, Carpenter AB, Friedman H, Friedman AH, Keir ST, He J, He Y, McLendon RE, Herndon JE 2nd, Yan H, Bigner DD. Killela PJ, et al. Among authors: yan h. Oncotarget. 2014 Mar 30;5(6):1515-25. doi: 10.18632/oncotarget.1765. Oncotarget. 2014. PMID: 24722048 Free PMC article.
Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas.
Zhang L, Chen LH, Wan H, Yang R, Wang Z, Feng J, Yang S, Jones S, Wang S, Zhou W, Zhu H, Killela PJ, Zhang J, Wu Z, Li G, Hao S, Wang Y, Webb JB, Friedman HS, Friedman AH, McLendon RE, He Y, Reitman ZJ, Bigner DD, Yan H. Zhang L, et al. Among authors: yan h. Nat Genet. 2014 Jul;46(7):726-30. doi: 10.1038/ng.2995. Epub 2014 Jun 1. Nat Genet. 2014. PMID: 24880341 Free PMC article.
MTAP Loss Promotes Stemness in Glioblastoma and Confers Unique Susceptibility to Purine Starvation.
Hansen LJ, Sun R, Yang R, Singh SX, Chen LH, Pirozzi CJ, Moure CJ, Hemphill C, Carpenter AB, Healy P, Ruger RC, Chen CJ, Greer PK, Zhao F, Spasojevic I, Grenier C, Huang Z, Murphy SK, McLendon RE, Friedman HS, Friedman AH, Herndon JE 2nd, Sampson JH, Keir ST, Bigner DD, Yan H, He Y. Hansen LJ, et al. Among authors: yan h. Cancer Res. 2019 Jul 1;79(13):3383-3394. doi: 10.1158/0008-5472.CAN-18-1010. Epub 2019 Apr 30. Cancer Res. 2019. PMID: 31040154 Free PMC article.
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