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15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis.
Myung SJ, Rerko RM, Yan M, Platzer P, Guda K, Dotson A, Lawrence E, Dannenberg AJ, Lovgren AK, Luo G, Pretlow TP, Newman RA, Willis J, Dawson D, Markowitz SD. Myung SJ, et al. Among authors: markowitz sd. Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):12098-102. doi: 10.1073/pnas.0603235103. Epub 2006 Jul 31. Proc Natl Acad Sci U S A. 2006. PMID: 16880406 Free PMC article.
15-Hydroxyprostaglandin dehydrogenase inactivation as a mechanism of resistance to celecoxib chemoprevention of colon tumors.
Yan M, Myung SJ, Fink SP, Lawrence E, Lutterbaugh J, Yang P, Zhou X, Liu D, Rerko RM, Willis J, Dawson D, Tai HH, Barnholtz-Sloan JS, Newman RA, Bertagnolli MM, Markowitz SD. Yan M, et al. Among authors: markowitz sd. Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9409-13. doi: 10.1073/pnas.0902367106. Epub 2009 May 22. Proc Natl Acad Sci U S A. 2009. PMID: 19470469 Free PMC article. Clinical Trial.
TISSUE REGENERATION. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration.
Zhang Y, Desai A, Yang SY, Bae KB, Antczak MI, Fink SP, Tiwari S, Willis JE, Williams NS, Dawson DM, Wald D, Chen WD, Wang Z, Kasturi L, Larusch GA, He L, Cominelli F, Di Martino L, Djuric Z, Milne GL, Chance M, Sanabria J, Dealwis C, Mikkola D, Naidoo J, Wei S, Tai HH, Gerson SL, Ready JM, Posner B, Willson JK, Markowitz SD. Zhang Y, et al. Among authors: markowitz sd. Science. 2015 Jun 12;348(6240):aaa2340. doi: 10.1126/science.aaa2340. Science. 2015. PMID: 26068857 Free PMC article.
Inhibitors of 15-Prostaglandin Dehydrogenase To Potentiate Tissue Repair.
Antczak MI, Zhang Y, Wang C, Doran J, Naidoo J, Voruganti S, Williams NS, Markowitz SD, Ready JM. Antczak MI, et al. Among authors: markowitz sd. J Med Chem. 2017 May 11;60(9):3979-4001. doi: 10.1021/acs.jmedchem.7b00271. Epub 2017 Apr 25. J Med Chem. 2017. PMID: 28398755 Free PMC article.
Therapeutic targeting of 15-PGDH in murine pulmonary fibrosis.
Smith JNP, Witkin MD, Jogasuria AP, Christo KF, Raffay TM, Markowitz SD, Desai AB. Smith JNP, et al. Among authors: markowitz sd. Sci Rep. 2020 Jul 15;10(1):11657. doi: 10.1038/s41598-020-68336-0. Sci Rep. 2020. PMID: 32669620 Free PMC article.
Inhibition of 15-PGDH prevents ischemic renal injury by the PGE2/EP4 signaling pathway mediating vasodilation, increased renal blood flow, and increased adenosine/A2A receptors.
Kim HJ, Kim SH, Kim M, Baik H, Park SJ, Kang MS, Kim DH, Kim BW, Markowitz SD, Bae KB. Kim HJ, et al. Among authors: markowitz sd. Am J Physiol Renal Physiol. 2020 Dec 1;319(6):F1054-F1066. doi: 10.1152/ajprenal.00103.2020. Epub 2020 Nov 2. Am J Physiol Renal Physiol. 2020. PMID: 33135478 Free PMC article.
269 results