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Page 1
BET bromodomain inhibitors regulate keratinocyte plasticity.
Schutzius G, Kolter C, Bergling S, Tortelli F, Fuchs F, Renner S, Guagnano V, Cotesta S, Rueeger H, Faller M, Bouchez L, Salathe A, Nigsch F, Richards SM, Louis M, Gruber V, Aebi A, Turner J, Grandjean F, Li J, Dimitri C, Thomas JR, Schirle M, Blank J, Drueckes P, Vaupel A, Tiedt R, Manley PW, Klopp J, Hemmig R, Zink F, Leroy N, Carbone W, Roma G, Keller CG, Dales N, Beyerbach A, Zimmerlin A, Bonenfant D, Terranova R, Berwick A, Sahambi S, Reynolds A, Jennings LL, Ruffner H, Tarsa P, Bouwmeester T, Driver V, Frederiksen M, Lohmann F, Kirkland S. Schutzius G, et al. Among authors: hemmig r. Nat Chem Biol. 2021 Mar;17(3):280-290. doi: 10.1038/s41589-020-00716-z. Epub 2021 Jan 18. Nat Chem Biol. 2021. PMID: 33462494
Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery.
Jahnke W, Rondeau JM, Cotesta S, Marzinzik A, Pellé X, Geiser M, Strauss A, Götte M, Bitsch F, Hemmig R, Henry C, Lehmann S, Glickman JF, Roddy TP, Stout SJ, Green JR. Jahnke W, et al. Among authors: hemmig r. Nat Chem Biol. 2010 Sep;6(9):660-6. doi: 10.1038/nchembio.421. Epub 2010 Aug 15. Nat Chem Biol. 2010. PMID: 20711197
Development of autotaxin inhibitors: A series of tetrazole cinnamides.
Thomson CG, Le Grand D, Dowling M, Beattie D, Elphick L, Faller M, Freeman M, Hardaker E, Head V, Hemmig R, Hill J, Lister A, Pascoe D, Rieffel S, Shrestha B, Steward O, Zink F. Thomson CG, et al. Among authors: hemmig r. Bioorg Med Chem Lett. 2021 Jan 1;31:127663. doi: 10.1016/j.bmcl.2020.127663. Epub 2020 Nov 4. Bioorg Med Chem Lett. 2021. PMID: 33160025
Structure-Based Optimization of a Fragment-like TLR8 Binding Screening Hit to an In Vivo Efficacious TLR7/8 Antagonist.
Betschart C, Faller M, Zink F, Hemmig R, Blank J, Vangrevelinghe E, Bourrel M, Glatthar R, Behnke D, Barker K, Heizmann A, Angst D, Nimsgern P, Jacquier S, Junt T, Zipfel G, Ruzzante G, Loetscher P, Limonta S, Hawtin S, Andre CB, Boulay T, Feifel R, Knoepfel T. Betschart C, et al. Among authors: hemmig r. ACS Med Chem Lett. 2022 Mar 10;13(4):658-664. doi: 10.1021/acsmedchemlett.1c00696. eCollection 2022 Apr 14. ACS Med Chem Lett. 2022. PMID: 35450354 Free PMC article.
Discovery of the TLR7/8 Antagonist MHV370 for Treatment of Systemic Autoimmune Diseases.
Alper P, Betschart C, André C, Boulay T, Cheng D, Deane J, Faller M, Feifel R, Glatthar R, Han D, Hemmig R, Jiang T, Knoepfel T, Maginnis J, Mutnick D, Pei W, Ruzzante G, Syka P, Zhang G, Zhang Y, Zink F, Zipfel G, Hawtin S, Junt T, Michellys PY. Alper P, et al. Among authors: hemmig r. ACS Med Chem Lett. 2023 Jul 31;14(8):1054-1062. doi: 10.1021/acsmedchemlett.3c00136. eCollection 2023 Aug 10. ACS Med Chem Lett. 2023. PMID: 37583811 Free PMC article.
A General Strategy for Targeting Drugs to Bone.
Jahnke W, Bold G, Marzinzik AL, Ofner S, Pellé X, Cotesta S, Bourgier E, Lehmann S, Henry C, Hemmig R, Stauffer F, Hartwieg JC, Green JR, Rondeau JM. Jahnke W, et al. Among authors: hemmig r. Angew Chem Int Ed Engl. 2015 Nov 23;54(48):14575-9. doi: 10.1002/anie.201507064. Epub 2015 Oct 12. Angew Chem Int Ed Engl. 2015. PMID: 26457482
Ranking of high-affinity ligands by NMR spectroscopy.
Zhang X, Sänger A, Hemmig R, Jahnke W. Zhang X, et al. Among authors: hemmig r. Angew Chem Int Ed Engl. 2009;48(36):6691-4. doi: 10.1002/anie.200902591. Angew Chem Int Ed Engl. 2009. PMID: 19650100 No abstract available.
NMR reporter screening for the detection of high-affinity ligands.
Jahnke W, Floersheim P, Ostermeier C, Zhang X, Hemmig R, Hurth K, Uzunov DP. Jahnke W, et al. Among authors: hemmig r. Angew Chem Int Ed Engl. 2002 Sep 16;41(18):3420-3. doi: 10.1002/1521-3773(20020916)41:18<3420::AID-ANIE3420>3.0.CO;2-E. Angew Chem Int Ed Engl. 2002. PMID: 12298051 No abstract available.
13 results