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MAIT cell plasticity enables functional adaptation that drives antibacterial immune protection.
Wang H, Souter MNT, de Lima Moreira M, Li S, Zhou Y, Nelson AG, Yu J, Meehan LJ, Meehan BS, Eckle SBG, Lee HJ, Schröder J, Haque A, Mak JYW, Fairlie DP, McCluskey J, Wang Z, Chen Z, Corbett AJ. Wang H, et al. Among authors: mccluskey j. Sci Immunol. 2024 Dec 6;9(102):eadp9841. doi: 10.1126/sciimmunol.adp9841. Epub 2024 Dec 6. Sci Immunol. 2024. PMID: 39642244
MR1 presents vitamin B6-related compounds for recognition by MR1-reactive T cells.
McInerney MP, Awad W, Souter MNT, Kang Y, Wang CJH, Chan Yew Poa K, Abdelaal MR, Le NH, Shepherd CM, McNeice C, Meehan LJ, Nelson AG, Raynes JM, Mak JYW, McCluskey J, Chen Z, Ang CS, Fairlie DP, Le Nours J, Illing PT, Rossjohn J, Purcell AW. McInerney MP, et al. Among authors: mccluskey j. Proc Natl Acad Sci U S A. 2024 Dec 3;121(49):e2414792121. doi: 10.1073/pnas.2414792121. Epub 2024 Nov 26. Proc Natl Acad Sci U S A. 2024. PMID: 39589872
Vertical Transplacental Infections.
McCluskey JM, Sato AI. McCluskey JM, et al. 2024 Aug 16. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. 2024 Aug 16. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 38861626 Free Books & Documents.
MAIT cell-MR1 reactivity is highly conserved across multiple divergent species.
Edmans MD, Connelley TK, Morgan S, Pediongco TJ, Jayaraman S, Juno JA, Meehan BS, Dewar PM, Maze EA, Roos EO, Paudyal B, Mak JYW, Liu L, Fairlie DP, Wang H, Corbett AJ, McCluskey J, Benedictus L, Tchilian E, Klenerman P, Eckle SBG. Edmans MD, et al. Among authors: mccluskey j. J Biol Chem. 2024 Jun;300(6):107338. doi: 10.1016/j.jbc.2024.107338. Epub 2024 May 3. J Biol Chem. 2024. PMID: 38705391 Free PMC article.
Synthetic 5-amino-6-D-ribitylaminouracil paired with inflammatory stimuli facilitates MAIT cell expansion in vivo.
Nelson AG, Wang H, Dewar PM, Eddy EM, Li S, Lim XY, Patton T, Zhou Y, Pediongco TJ, Meehan LJ, Meehan BS, Mak JYW, Fairlie DP, Stent AW, Kjer-Nielsen L, McCluskey J, Eckle SBG, Corbett AJ, Souter MNT, Chen Z. Nelson AG, et al. Among authors: mccluskey j. Front Immunol. 2023 Aug 31;14:1109759. doi: 10.3389/fimmu.2023.1109759. eCollection 2023. Front Immunol. 2023. PMID: 37720229 Free PMC article.
The allopurinol metabolite, oxypurinol, drives oligoclonal expansions of drug-reactive T cells in resolved hypersensitivity cases and drug-naïve healthy donors.
Mifsud NA, Illing PT, Ho R, Tuomisto JE, Fettke H, Mullan KA, McCluskey J, Rossjohn J, Vivian J, Reantragoon R, Purcell AW. Mifsud NA, et al. Among authors: mccluskey j. Allergy. 2023 Nov;78(11):2980-2993. doi: 10.1111/all.15814. Epub 2023 Jul 14. Allergy. 2023. PMID: 37452515 Free PMC article.
456 results