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Targeting the muscarinic M1 receptor with a selective, brain-penetrant antagonist to promote remyelination in multiple sclerosis.
Poon MM, Lorrain KI, Stebbins KJ, Edu GC, Broadhead AR, Lorenzana AJ, Roppe JR, Baccei JM, Baccei CS, Chen AC, Green AJ, Lorrain DS, Chan JR. Poon MM, et al. Among authors: lorenzana aj. Proc Natl Acad Sci U S A. 2024 Aug 6;121(32):e2407974121. doi: 10.1073/pnas.2407974121. Epub 2024 Jul 31. Proc Natl Acad Sci U S A. 2024. PMID: 39083422 Free PMC article.
Discovery of a brain penetrant small molecule antagonist targeting LPA1 receptors to reduce neuroinflammation and promote remyelination in multiple sclerosis.
Poon MM, Lorrain KI, Stebbins KJ, Edu GC, Broadhead AR, Lorenzana AO, Paulson BE, Baccei CS, Roppe JR, Schrader TO, Valdez LJ, Xiong Y, Chen AC, Lorrain DS. Poon MM, et al. Among authors: lorenzana ao. Sci Rep. 2024 May 8;14(1):10573. doi: 10.1038/s41598-024-61369-9. Sci Rep. 2024. PMID: 38719983 Free PMC article.
Identification and In Vivo Evaluation of Myelination Agent PIPE-3297, a Selective Kappa Opioid Receptor Agonist Devoid of β-Arrestin-2 Recruitment Efficacy.
Schrader TO, Lorrain KI, Bagnol D, Edu GC, Broadhead A, Baccei C, Poon MM, Stebbins KJ, Xiong Y, Lorenzana AO, Chan JR, Green AJ, Lorrain DS, Chen A. Schrader TO, et al. Among authors: lorenzana ao. ACS Chem Neurosci. 2024 Feb 7;15(3):685-698. doi: 10.1021/acschemneuro.3c00807. Epub 2024 Jan 24. ACS Chem Neurosci. 2024. PMID: 38265210
Clinical Features and Risk Factors Associated With Multisystem Inflammatory Syndrome in Children With Cancer and COVID-19.
Martin SD, Davis ES, Dai C, Boal LH, Araya B, Brackett J, Dickens D, Kahn A, Martinez I, Sharma A, Schwalm C, Aguayo-Hiraldo P, Bhatia S, Levine JM, Johnston EE, Wolfson JA; Pediatric Oncology COVID-19 Case Consortium. Martin SD, et al. JAMA Oncol. 2023 Aug 1;9(8):1108-1112. doi: 10.1001/jamaoncol.2023.0525. JAMA Oncol. 2023. PMID: 37166782 Free PMC article.
59 results