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Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites.
Dorjsuren D, Eastman RT, Wicht KJ, Jansen D, Talley DC, Sigmon BA, Zakharov AV, Roncal N, Girvin AT, Antonova-Koch Y, Will PM, Shah P, Sun H, Klumpp-Thomas C, Mok S, Yeo T, Meister S, Marugan JJ, Ross LS, Xu X, Maloney DJ, Jadhav A, Mott BT, Sciotti RJ, Winzeler EA, Waters NC, Campbell RF, Huang W, Simeonov A, Fidock DA. Dorjsuren D, et al. Among authors: eastman rt. Sci Rep. 2021 Jan 22;11(1):2121. doi: 10.1038/s41598-021-81486-z. Sci Rep. 2021. PMID: 33483532 Free PMC article.
Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum.
Dharia NV, Sidhu AB, Cassera MB, Westenberger SJ, Bopp SE, Eastman RT, Plouffe D, Batalov S, Park DJ, Volkman SK, Wirth DF, Zhou Y, Fidock DA, Winzeler EA. Dharia NV, et al. Among authors: eastman rt. Genome Biol. 2009 Feb 13;10(2):R21. doi: 10.1186/gb-2009-10-2-r21. Genome Biol. 2009. PMID: 19216790 Free PMC article.
Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue.
Adjalley SH, Johnston GL, Li T, Eastman RT, Ekland EH, Eappen AG, Richman A, Sim BK, Lee MC, Hoffman SL, Fidock DA. Adjalley SH, et al. Among authors: eastman rt. Proc Natl Acad Sci U S A. 2011 Nov 22;108(47):E1214-23. doi: 10.1073/pnas.1112037108. Epub 2011 Oct 31. Proc Natl Acad Sci U S A. 2011. PMID: 22042867 Free PMC article.
High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations.
Mott BT, Eastman RT, Guha R, Sherlach KS, Siriwardana A, Shinn P, McKnight C, Michael S, Lacerda-Queiroz N, Patel PR, Khine P, Sun H, Kasbekar M, Aghdam N, Fontaine SD, Liu D, Mierzwa T, Mathews-Griner LA, Ferrer M, Renslo AR, Inglese J, Yuan J, Roepe PD, Su XZ, Thomas CJ. Mott BT, et al. Among authors: eastman rt. Sci Rep. 2015 Sep 25;5:13891. doi: 10.1038/srep13891. Sci Rep. 2015. PMID: 26403635 Free PMC article.
70 results