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Epithelial Sodium Channel and Salt-Sensitive Hypertension.
Mutchler SM, Kirabo A, Kleyman TR. Mutchler SM, et al. Among authors: kleyman tr. Hypertension. 2021 Mar 3;77(3):759-767. doi: 10.1161/HYPERTENSIONAHA.120.14481. Epub 2021 Jan 25. Hypertension. 2021. PMID: 33486988 Free PMC article. Review.
Base of the thumb domain modulates epithelial sodium channel gating.
Shi S, Ghosh DD, Okumura S, Carattino MD, Kashlan OB, Sheng S, Kleyman TR. Shi S, et al. Among authors: kleyman tr. J Biol Chem. 2011 Apr 29;286(17):14753-61. doi: 10.1074/jbc.M110.191734. Epub 2011 Mar 2. J Biol Chem. 2011. PMID: 21367859 Free PMC article.
Multiple residues in the distal C terminus of the α-subunit have roles in modulating human epithelial sodium channel activity.
Mueller GM, Yan W, Copelovitch L, Jarman S, Wang Z, Kinlough CL, Tolino MA, Hughey RP, Kleyman TR, Rubenstein RC. Mueller GM, et al. Among authors: kleyman tr. Am J Physiol Renal Physiol. 2012 Jul 15;303(2):F220-8. doi: 10.1152/ajprenal.00493.2011. Epub 2012 May 9. Am J Physiol Renal Physiol. 2012. PMID: 22573385 Free PMC article.
We previously reported that the A663T polymorphism in the C terminus of the alpha-subunit altered ENaC functional and surface expression in Xenopus laevis oocytes (Samaha FF, Rubenstein RC, Yan W, Ramkumar M, Levy DI, Ahn YJ, Sheng S, Kleyman TR. J Biol Chem 279: 23 …
We previously reported that the A663T polymorphism in the C terminus of the alpha-subunit altered ENaC functional and surface expression in …
Gain-of-function variant of the human epithelial sodium channel.
Chen J, Kleyman TR, Sheng S. Chen J, et al. Among authors: kleyman tr. Am J Physiol Renal Physiol. 2013 Jan 15;304(2):F207-13. doi: 10.1152/ajprenal.00563.2012. Epub 2012 Nov 7. Am J Physiol Renal Physiol. 2013. PMID: 23136006 Free PMC article.
240 results