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Making Better Dose Decisions: Using Exposure-Response Modeling to Integrate Efficacy Outcome of Two Phase IIb Clinical Trials of Ubrogepant for Migraine Treatment.
Li CC, Voss T, Kowalski K, Yang B, Kleijn HJ, Jones CJ, Bosch R, Michelson D, DeAngelis M, Xu Y, Xie I, Kothare PA. Li CC, et al. Among authors: kleijn hj. Clin Transl Sci. 2020 May;13(3):482-490. doi: 10.1111/cts.12730. Epub 2020 Jan 16. Clin Transl Sci. 2020. PMID: 31758661 Free PMC article. Clinical Trial.
Population PK Analyses of Ubrogepant (MK-1602), a CGRP Receptor Antagonist: Enriching In-Clinic Plasma PK Sampling With Outpatient Dried Blood Spot Sampling.
Li CC, Dockendorf M, Kowalski K, Yang B, Xu Y, Xie I, Kleijn HJ, Bosch R, Jones C, Thornton B, Marcantonio EE, Voss T, Bateman KP, Kothare PA. Li CC, et al. Among authors: kleijn hj. J Clin Pharmacol. 2018 Mar;58(3):294-303. doi: 10.1002/jcph.1021. Epub 2017 Nov 14. J Clin Pharmacol. 2018. PMID: 29136283 Clinical Trial.
A PK-PD model-based assessment of sugammadex effects on coagulation parameters.
Bosch R, van Lierop MJ, de Kam PJ, Kruithof AC, Burggraaf J, de Greef R, Visser SA, Johnson-Levonas AO, Kleijn HJ. Bosch R, et al. Among authors: kleijn hj. Eur J Pharm Sci. 2016 Mar 10;84:9-17. doi: 10.1016/j.ejps.2015.12.028. Epub 2015 Dec 30. Eur J Pharm Sci. 2016. PMID: 26747019 Clinical Trial.
24 results