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Small-molecule probe reveals a kinase cascade that links stress signaling to TCF/LEF and Wnt responsiveness.
Cheng J, Tsuda M, Okolotowicz K, Dwyer M, Bushway PJ, Colas AR, Lancman JJ, Schade D, Perea-Gil I, Bruyneel AAN, Lee J, Vadgama N, Quach J, McKeithan WL, Biechele TL, Wu JC, Moon RT, Si Dong PD, Karakikes I, Cashman JR, Mercola M. Cheng J, et al. Among authors: okolotowicz k. Cell Chem Biol. 2021 May 20;28(5):625-635.e5. doi: 10.1016/j.chembiol.2021.01.001. Epub 2021 Jan 26. Cell Chem Biol. 2021. PMID: 33503403 Free PMC article.
Novel tertiary sulfonamides as potent anti-cancer agents.
Okolotowicz KJ, Dwyer M, Ryan D, Cheng J, Cashman EA, Moore S, Mercola M, Cashman JR. Okolotowicz KJ, et al. Bioorg Med Chem. 2018 Aug 15;26(15):4441-4451. doi: 10.1016/j.bmc.2018.07.042. Epub 2018 Jul 25. Bioorg Med Chem. 2018. PMID: 30075999
Reengineering an Antiarrhythmic Drug Using Patient hiPSC Cardiomyocytes to Improve Therapeutic Potential and Reduce Toxicity.
McKeithan WL, Feyen DAM, Bruyneel AAN, Okolotowicz KJ, Ryan DA, Sampson KJ, Potet F, Savchenko A, Gómez-Galeno J, Vu M, Serrano R, George AL Jr, Kass RS, Cashman JR, Mercola M. McKeithan WL, et al. Among authors: okolotowicz kj. Cell Stem Cell. 2020 Nov 5;27(5):813-821.e6. doi: 10.1016/j.stem.2020.08.003. Epub 2020 Sep 14. Cell Stem Cell. 2020. PMID: 32931730 Free PMC article.
Human iPSC-derived cardiomyocytes and pyridyl-phenyl mexiletine analogs.
Johnson M, Gomez-Galeno J, Ryan D, Okolotowicz K, McKeithan WL, Sampson KJ, Kass RS, Mercola M, Cashman JR. Johnson M, et al. Among authors: okolotowicz k. Bioorg Med Chem Lett. 2021 Aug 15;46:128162. doi: 10.1016/j.bmcl.2021.128162. Epub 2021 May 29. Bioorg Med Chem Lett. 2021. PMID: 34062251
20 results