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Pseudomonas aeruginosa Elastase Contributes to the Establishment of Chronic Lung Colonization and Modulates the Immune Response in a Murine Model.
Cigana C, Castandet J, Sprynski N, Melessike M, Beyria L, Ranucci S, Alcalá-Franco B, Rossi A, Bragonzi A, Zalacain M, Everett M. Cigana C, et al. Among authors: everett m. Front Microbiol. 2021 Jan 12;11:620819. doi: 10.3389/fmicb.2020.620819. eCollection 2020. Front Microbiol. 2021. PMID: 33510733 Free PMC article.
Discovery of a Novel Metallo-β-Lactamase Inhibitor That Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacteriaceae.
Everett M, Sprynski N, Coelho A, Castandet J, Bayet M, Bougnon J, Lozano C, Davies DT, Leiris S, Zalacain M, Morrissey I, Magnet S, Holden K, Warn P, De Luca F, Docquier JD, Lemonnier M. Everett M, et al. Antimicrob Agents Chemother. 2018 Apr 26;62(5):e00074-18. doi: 10.1128/AAC.00074-18. Print 2018 May. Antimicrob Agents Chemother. 2018. PMID: 29530861 Free PMC article.
SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model.
Leiris S, Coelho A, Castandet J, Bayet M, Lozano C, Bougnon J, Bousquet J, Everett M, Lemonnier M, Sprynski N, Zalacain M, Pallin TD, Cramp MC, Jennings N, Raphy G, Jones MW, Pattipati R, Shankar B, Sivasubrahmanyam R, Soodhagani AK, Juventhala RR, Pottabathini N, Pothukanuri S, Benvenuti M, Pozzi C, Mangani S, De Luca F, Cerboni G, Docquier JD, Davies DT. Leiris S, et al. Among authors: everett m. ACS Infect Dis. 2019 Jan 11;5(1):131-140. doi: 10.1021/acsinfecdis.8b00246. Epub 2018 Nov 30. ACS Infect Dis. 2019. PMID: 30427656 Free PMC article.
Pharmacodynamics of the Novel Metallo-β-Lactamase Inhibitor ANT2681 in Combination with Meropenem for the Treatment of Infections Caused by NDM-Producing Enterobacteriaceae.
Das S, Johnson A, McEntee L, Farrington N, Kirby A, Unsworth J, Jimenez-Valverde A, Kolamunnage-Dona R, Bousquet J, Alibaud L, Sable C, Zalacain M, Everett M, Hope W. Das S, et al. Among authors: everett m. Antimicrob Agents Chemother. 2020 Oct 20;64(11):e01076-20. doi: 10.1128/AAC.01076-20. Print 2020 Oct 20. Antimicrob Agents Chemother. 2020. PMID: 32778549 Free PMC article.
ANT2681: SAR Studies Leading to the Identification of a Metallo-β-lactamase Inhibitor with Potential for Clinical Use in Combination with Meropenem for the Treatment of Infections Caused by NDM-Producing Enterobacteriaceae.
Davies DT, Leiris S, Sprynski N, Castandet J, Lozano C, Bousquet J, Zalacain M, Vasa S, Dasari PK, Pattipati R, Vempala N, Gujjewar S, Godi S, Jallala R, Sathyap RR, Darshanoju NA, Ravu VR, Juventhala RR, Pottabathini N, Sharma S, Pothukanuri S, Holden K, Warn P, Marcoccia F, Benvenuti M, Pozzi C, Mangani S, Docquier JD, Lemonnier M, Everett M. Davies DT, et al. Among authors: everett m. ACS Infect Dis. 2020 Sep 11;6(9):2419-2430. doi: 10.1021/acsinfecdis.0c00207. Epub 2020 Aug 20. ACS Infect Dis. 2020. PMID: 32786279
Discovery of ANT3310, a Novel Broad-Spectrum Serine β-Lactamase Inhibitor of the Diazabicyclooctane Class, Which Strongly Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacterales and Acinetobacter baumannii.
Davies DT, Leiris S, Zalacain M, Sprynski N, Castandet J, Bousquet J, Lozano C, Llanos A, Alibaud L, Vasa S, Pattipati R, Valige R, Kummari B, Pothukanuri S, De Piano C, Morrissey I, Holden K, Warn P, Marcoccia F, Benvenuti M, Pozzi C, Tassone G, Mangani S, Docquier JD, Pallin D, Elliot R, Lemonnier M, Everett M. Davies DT, et al. Among authors: everett m. J Med Chem. 2020 Dec 24;63(24):15802-15820. doi: 10.1021/acs.jmedchem.0c01535. Epub 2020 Dec 11. J Med Chem. 2020. PMID: 33306385
Virtual Screening Approach to Identifying a Novel and Tractable Series of Pseudomonas aeruginosa Elastase Inhibitors.
Leiris S, Davies DT, Sprynski N, Castandet J, Beyria L, Bodnarchuk MS, Sutton JM, Mullins TMG, Jones MW, Forrest AK, Pallin TD, Karunakar P, Martha SK, Parusharamulu B, Ramula R, Kotha V, Pottabathini N, Pothukanuri S, Lemonnier M, Everett M. Leiris S, et al. Among authors: everett m. ACS Med Chem Lett. 2021 Jan 15;12(2):217-227. doi: 10.1021/acsmedchemlett.0c00554. eCollection 2021 Feb 11. ACS Med Chem Lett. 2021. PMID: 33603968 Free PMC article.
Novel Specific Metallo-β-Lactamase Inhibitor ANT2681 Restores Meropenem Activity to Clinically Effective Levels against NDM-Positive Enterobacterales.
Zalacain M, Lozano C, Llanos A, Sprynski N, Valmont T, De Piano C, Davies D, Leiris S, Sable C, Ledoux A, Morrissey I, Lemonnier M, Everett M. Zalacain M, et al. Among authors: everett m. Antimicrob Agents Chemother. 2021 May 18;65(6):e00203-21. doi: 10.1128/AAC.00203-21. Print 2021 May 18. Antimicrob Agents Chemother. 2021. PMID: 33820763 Free PMC article.
391 results