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New dual ATP-competitive inhibitors of bacterial DNA gyrase and topoisomerase IV active against ESKAPE pathogens.
Durcik M, Nyerges Á, Skok Ž, Skledar DG, Trontelj J, Zidar N, Ilaš J, Zega A, Cruz CD, Tammela P, Welin M, Kimbung YR, Focht D, Benek O, Révész T, Draskovits G, Szili PÉ, Daruka L, Pál C, Kikelj D, Mašič LP, Tomašič T. Durcik M, et al. Among authors: pal c. Eur J Med Chem. 2021 Mar 5;213:113200. doi: 10.1016/j.ejmech.2021.113200. Epub 2021 Jan 22. Eur J Med Chem. 2021. PMID: 33524686
Conditional DNA repair mutants enable highly precise genome engineering.
Nyerges Á, Csorgő B, Nagy I, Latinovics D, Szamecz B, Pósfai G, Pál C. Nyerges Á, et al. Among authors: pal c. Nucleic Acids Res. 2014 Apr;42(8):e62. doi: 10.1093/nar/gku105. Epub 2014 Feb 5. Nucleic Acids Res. 2014. PMID: 24500200 Free PMC article.
Genome-Wide Abolishment of Mobile Genetic Elements Using Genome Shuffling and CRISPR/Cas-Assisted MAGE Allows the Efficient Stabilization of a Bacterial Chassis.
Umenhoffer K, Draskovits G, Nyerges Á, Karcagi I, Bogos B, Tímár E, Csörgő B, Herczeg R, Nagy I, Fehér T, Pál C, Pósfai G. Umenhoffer K, et al. Among authors: pal c. ACS Synth Biol. 2017 Aug 18;6(8):1471-1483. doi: 10.1021/acssynbio.6b00378. Epub 2017 Apr 26. ACS Synth Biol. 2017. PMID: 28426191
New N-phenylpyrrolamide DNA gyrase B inhibitors: Optimization of efficacy and antibacterial activity.
Durcik M, Lovison D, Skok Ž, Durante Cruz C, Tammela P, Tomašič T, Benedetto Tiz D, Draskovits G, Nyerges Á, Pál C, Ilaš J, Peterlin Mašič L, Kikelj D, Zidar N. Durcik M, et al. Among authors: pal c. Eur J Med Chem. 2018 Jun 25;154:117-132. doi: 10.1016/j.ejmech.2018.05.011. Epub 2018 May 10. Eur J Med Chem. 2018. PMID: 29778894 Free PMC article.
Antibiotic-resistant bacteria show widespread collateral sensitivity to antimicrobial peptides.
Lázár V, Martins A, Spohn R, Daruka L, Grézal G, Fekete G, Számel M, Jangir PK, Kintses B, Csörgő B, Nyerges Á, Györkei Á, Kincses A, Dér A, Walter FR, Deli MA, Urbán E, Hegedűs Z, Olajos G, Méhi O, Bálint B, Nagy I, Martinek TA, Papp B, Pál C. Lázár V, et al. Among authors: pal c. Nat Microbiol. 2018 Jun;3(6):718-731. doi: 10.1038/s41564-018-0164-0. Epub 2018 May 24. Nat Microbiol. 2018. PMID: 29795541 Free PMC article.
393 results