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Inhibition of longevity regulator PAPP-A modulates tissue homeostasis via restraint of mesenchymal stromal cells.
Mohrin M, Liu J, Zavala-Solorio J, Bhargava S, Maxwell Trumble J, Brito A, Hu D, Brooks D, Koukos G, Alabdulaaly L, Paw JS, Hake K, Kolumam G, Bouxsein ML, Baron R, Kutskova Y, Freund A. Mohrin M, et al. Among authors: kolumam g. Aging Cell. 2021 Mar;20(3):e13313. doi: 10.1111/acel.13313. Epub 2021 Feb 9. Aging Cell. 2021. PMID: 33561324 Free PMC article.
Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1.
Wu AL, Kolumam G, Stawicki S, Chen Y, Li J, Zavala-Solorio J, Phamluong K, Feng B, Li L, Marsters S, Kates L, van Bruggen N, Leabman M, Wong A, West D, Stern H, Luis E, Kim HS, Yansura D, Peterson AS, Filvaroff E, Wu Y, Sonoda J. Wu AL, et al. Among authors: kolumam g. Sci Transl Med. 2011 Dec 14;3(113):113ra126. doi: 10.1126/scitranslmed.3002669. Sci Transl Med. 2011. PMID: 22174314
Furin-cleaved proprotein convertase subtilisin/kexin type 9 (PCSK9) is active and modulates low density lipoprotein receptor and serum cholesterol levels.
Lipari MT, Li W, Moran P, Kong-Beltran M, Sai T, Lai J, Lin SJ, Kolumam G, Zavala-Solorio J, Izrael-Tomasevic A, Arnott D, Wang J, Peterson AS, Kirchhofer D. Lipari MT, et al. Among authors: kolumam g. J Biol Chem. 2012 Dec 21;287(52):43482-91. doi: 10.1074/jbc.M112.380618. Epub 2012 Nov 7. J Biol Chem. 2012. PMID: 23135270 Free PMC article.
Glucagon Couples Hepatic Amino Acid Catabolism to mTOR-Dependent Regulation of α-Cell Mass.
Solloway MJ, Madjidi A, Gu C, Eastham-Anderson J, Clarke HJ, Kljavin N, Zavala-Solorio J, Kates L, Friedman B, Brauer M, Wang J, Fiehn O, Kolumam G, Stern H, Lowe JB, Peterson AS, Allan BB. Solloway MJ, et al. Among authors: kolumam g. Cell Rep. 2015 Jul 21;12(3):495-510. doi: 10.1016/j.celrep.2015.06.034. Epub 2015 Jul 9. Cell Rep. 2015. PMID: 26166562 Free article.
FGF21 mimetic antibody stimulates UCP1-independent brown fat thermogenesis via FGFR1/βKlotho complex in non-adipocytes.
Chen MZ, Chang JC, Zavala-Solorio J, Kates L, Thai M, Ogasawara A, Bai X, Flanagan S, Nunez V, Phamluong K, Ziai J, Newman R, Warming S, Kolumam G, Sonoda J. Chen MZ, et al. Among authors: kolumam g. Mol Metab. 2017 Nov;6(11):1454-1467. doi: 10.1016/j.molmet.2017.09.003. Epub 2017 Sep 18. Mol Metab. 2017. PMID: 29107292 Free PMC article.
46 results