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Neuronal non-CG methylation is an essential target for MeCP2 function.
Tillotson R, Cholewa-Waclaw J, Chhatbar K, Connelly JC, Kirschner SA, Webb S, Koerner MV, Selfridge J, Kelly DA, De Sousa D, Brown K, Lyst MJ, Kriaucionis S, Bird A. Tillotson R, et al. Among authors: koerner mv. Mol Cell. 2021 Mar 18;81(6):1260-1275.e12. doi: 10.1016/j.molcel.2021.01.011. Epub 2021 Feb 8. Mol Cell. 2021. PMID: 33561390 Free PMC article.
Radically truncated MeCP2 rescues Rett syndrome-like neurological defects.
Tillotson R, Selfridge J, Koerner MV, Gadalla KKE, Guy J, De Sousa D, Hector RD, Cobb SR, Bird A. Tillotson R, et al. Among authors: koerner mv. Nature. 2017 Oct 19;550(7676):398-401. doi: 10.1038/nature24058. Epub 2017 Oct 11. Nature. 2017. PMID: 29019980 Free PMC article.
A mutation-led search for novel functional domains in MeCP2.
Guy J, Alexander-Howden B, FitzPatrick L, DeSousa D, Koerner MV, Selfridge J, Bird A. Guy J, et al. Among authors: koerner mv. Hum Mol Genet. 2018 Jul 15;27(14):2531-2545. doi: 10.1093/hmg/ddy159. Hum Mol Genet. 2018. PMID: 29718204 Free PMC article.
Toxicity of overexpressed MeCP2 is independent of HDAC3 activity.
Koerner MV, FitzPatrick L, Selfridge J, Guy J, De Sousa D, Tillotson R, Kerr A, Sun Z, Lazar MA, Lyst MJ, Bird A. Koerner MV, et al. Genes Dev. 2018 Dec 1;32(23-24):1514-1524. doi: 10.1101/gad.320325.118. Epub 2018 Nov 21. Genes Dev. 2018. PMID: 30463906 Free PMC article.
Carbonyl reductase 1 amplifies glucocorticoid action in adipose tissue and impairs glucose tolerance in lean mice.
Bell RMB, Villalobos E, Nixon M, Miguelez-Crespo A, Murphy L, Fawkes A, Coutts A, Sharp MGF, Koerner MV, Allan E, Meijer OC, Houtman R, Odermatt A, Beck KR, Denham SG, Lee P, Homer NZM, Walker BR, Morgan RA. Bell RMB, et al. Among authors: koerner mv. Mol Metab. 2021 Jun;48:101225. doi: 10.1016/j.molmet.2021.101225. Epub 2021 Mar 27. Mol Metab. 2021. PMID: 33785425 Free PMC article.
Genomic imprinting-an epigenetic gene-regulatory model.
Koerner MV, Barlow DP. Koerner MV, et al. Curr Opin Genet Dev. 2010 Apr;20(2):164-70. doi: 10.1016/j.gde.2010.01.009. Epub 2010 Feb 12. Curr Opin Genet Dev. 2010. PMID: 20153958 Free PMC article. Review.
A downstream CpG island controls transcript initiation and elongation and the methylation state of the imprinted Airn macro ncRNA promoter.
Koerner MV, Pauler FM, Hudson QJ, Santoro F, Sawicka A, Guenzl PM, Stricker SH, Schichl YM, Latos PA, Klement RM, Warczok KE, Wojciechowski J, Seiser C, Kralovics R, Barlow DP. Koerner MV, et al. PLoS Genet. 2012;8(3):e1002540. doi: 10.1371/journal.pgen.1002540. Epub 2012 Mar 1. PLoS Genet. 2012. PMID: 22396659 Free PMC article.
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