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Neuronal non-CG methylation is an essential target for MeCP2 function.
Tillotson R, Cholewa-Waclaw J, Chhatbar K, Connelly JC, Kirschner SA, Webb S, Koerner MV, Selfridge J, Kelly DA, De Sousa D, Brown K, Lyst MJ, Kriaucionis S, Bird A. Tillotson R, et al. Among authors: selfridge j. Mol Cell. 2021 Mar 18;81(6):1260-1275.e12. doi: 10.1016/j.molcel.2021.01.011. Epub 2021 Feb 8. Mol Cell. 2021. PMID: 33561390 Free PMC article.
The role of MeCP2 in the brain.
Guy J, Cheval H, Selfridge J, Bird A. Guy J, et al. Among authors: selfridge j. Annu Rev Cell Dev Biol. 2011;27:631-52. doi: 10.1146/annurev-cellbio-092910-154121. Epub 2011 Jun 29. Annu Rev Cell Dev Biol. 2011. PMID: 21721946 Review.
Radically truncated MeCP2 rescues Rett syndrome-like neurological defects.
Tillotson R, Selfridge J, Koerner MV, Gadalla KKE, Guy J, De Sousa D, Hector RD, Cobb SR, Bird A. Tillotson R, et al. Among authors: selfridge j. Nature. 2017 Oct 19;550(7676):398-401. doi: 10.1038/nature24058. Epub 2017 Oct 11. Nature. 2017. PMID: 29019980 Free PMC article.
A mutation-led search for novel functional domains in MeCP2.
Guy J, Alexander-Howden B, FitzPatrick L, DeSousa D, Koerner MV, Selfridge J, Bird A. Guy J, et al. Among authors: selfridge j. Hum Mol Genet. 2018 Jul 15;27(14):2531-2545. doi: 10.1093/hmg/ddy159. Hum Mol Genet. 2018. PMID: 29718204 Free PMC article.
Toxicity of overexpressed MeCP2 is independent of HDAC3 activity.
Koerner MV, FitzPatrick L, Selfridge J, Guy J, De Sousa D, Tillotson R, Kerr A, Sun Z, Lazar MA, Lyst MJ, Bird A. Koerner MV, et al. Among authors: selfridge j. Genes Dev. 2018 Dec 1;32(23-24):1514-1524. doi: 10.1101/gad.320325.118. Epub 2018 Nov 21. Genes Dev. 2018. PMID: 30463906 Free PMC article.
121 results